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Scientific article
English

Structural Changes During the Transformation of Bacteriophage T4 Polyheads

Published inJournal of Molecular Biology, vol. 162, no. 3, p. 607-622
Publication date1982
Abstract

The shell of the bacteriophage T4 prehead is transformed after the maturation cleavages from a fragile to a highly chemically resistant structure. A “cleaved but anchored” shell, in which the capsid protein has been cleaved but expansion to the mature structure has not yet occurred, is thought to be an intermediate in the transformation. We have compared native, trypsinized, temperature-sensitive mutant, and cleaved but anchored polyheads for differences and similarities in their capsomeres. Our results show that the altered capsomeres of the cleaved but anchored state must be attributed to a conformational change in the subunits, and not simply to the loss of the amino-terminal peptide by proteolysis.

Affiliation Not a UNIGE publication
Funding
  • Autre - NSH AI 13165
  • Autre - NSH AI 18380
Citation (ISO format)
KISTLER, Joerg et al. Structural Changes During the Transformation of Bacteriophage T4 Polyheads. In: Journal of Molecular Biology, 1982, vol. 162, n° 3, p. 607–622. doi: 10.1016/0022-2836(82)90391-6
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ISSN of the journal0022-2836
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