In 2016, Swiss Health Authorities recognised the value of expanding the role of community pharmacists in primary care, particularly in the interprofessional management of patients with chronic diseases. They acknowledged the need to evaluate the effectiveness of an interprofessional patient support programme (Siscare) and to formulate recommendations for its effective implementation and sustainability in primary care in the French-speaking part of Switzerland. This PhD thesis illustrates the use of implementation science and clinical research to support and assess the implementation of Siscare with a focus on patients with type 2 diabetes (T2D) using a 15-month prospective, multicentre, observational, mixed-method cohort study, a hybrid type 2 implementation-effectiveness design, and the Framework for the Implementation of Services in Pharmacy (FISpH). This PhD thesis provides evidence regarding the ability to implement and the acceptability of Siscare among pharmacy teams, effective support for patients with T2D, and a promising start towards interprofessional collaborative practices.