Anti-PD-1-Induced Hidradenitis Suppurativa

Maillard, Alexia; Pastor, Damien; Merat, Rastine

doi:10.3390/dermatopathology8010007

Scientific article

Case report

English

Anti-PD-1-Induced Hidradenitis Suppurativa

Contributors

Maillard, Alexia; Pastor, Damien; Merat, Rastine

Published in

Dermatopathology, vol. 8, no. 1, p. 37-39

Publication date

2021

Abstract

Mucocutaneous adverse events are commonly observed under immune checkpoint inhibitors (ICIs) therapy. Here, we report the case of a 43-year-old male patient with a stage IIIC melanoma disease who developed hidradenitis suppurativa (HS) three months after the beginning of an anti-PD-1 (nivolumab) adjuvant therapy. The patient had no comorbidities other than obesity and severe acne during adolescence. After an unsuccessful course of lymecycline while he was still treated with nivolumab, he gradually improved under zinc gluconate therapy and, more importantly, after nivolumab cessation. HS is a recurrent follicular inflammatory disease in the apocrine gland-bearing areas of the body often associated with obesity, metabolic syndrome, tobacco smoking, inflammatory bowel diseases, psoriasis, and arthritis. In our patient, the latency period between drug initiation and onset of HS symptoms and the improvement after immunotherapy discontinuation, argued strongly in favor of an anti-PD-1-induced HS. Anti-PD-1 therapies often trigger T cells-mediated adverse events that mimic Th17-mediated inflammatory and neutrophilic diseases. We suggest that HS, as other pustular skin reactions and ICIs-induced neutrophilic colitis, can be part of the anti-PD-1 mucocutaneous adverse event spectrum.

Keywords

Anti-PD-1
Cutaneous immune-related adverse events
Hidradenitis suppurativa
Melanoma

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

MAILLARD, Alexia, PASTOR, Damien, MERAT, Rastine. Anti-PD-1-Induced Hidradenitis Suppurativa. In: Dermatopathology, 2021, vol. 8, n° 1, p. 37–39. doi: 10.3390/dermatopathology8010007

Article (Published version)

CC BY

Identifiers

PID : unige:150326
DOI : 10.3390/dermatopathology8010007
PMID : 33668724

Journal ISSN

2296-3529

248views

171downloads

Creation

08/03/2021 13:33:00

First validation

08/03/2021 13:33:00

Update

16/03/2023 00:14:29

Status update

16/03/2023 00:14:29

Last indexation

31/10/2024 21:35:03

Anti-PD-1-Induced Hidradenitis Suppurativa

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation