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Scientific article
English

The Transposition Frequency of IS1-flanked Transposons is a Function of Their Size

Published inJournal of Molecular Biology, vol. 154, no. 2, p. 229-243
Publication date1982
Abstract

We have measured the transposition frequencies of six IS1-flanked transposable elements ranging in size between 2.6 and 10.5 kb. The frequency of transposition decreases approximately exponentially with increasing length by two orders of magnitude over this size range, and is reduced by about half for each additional 1 kb of DNA. The simplest explanation for these results is that transposition occurs by a processive mechanism initiating at one end of the element and proceeding to the other extremity, with a constant probability of abortion per unit length of DNA.

Funding
  • Swiss National Science Foundation - 3.591.79
  • Swiss National Science Foundation - 3.493.79
Citation (ISO format)
CHANDLER, Michael, CLERGET, MICHEL OLIVIER, GALAS, David J. The Transposition Frequency of IS<i>1</i>-flanked Transposons is a Function of Their Size. In: Journal of Molecular Biology, 1982, vol. 154, n° 2, p. 229–243. doi: 10.1016/0022-2836(82)90062-6
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Article (Published version)
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Identifiers
ISSN of the journal0022-2836
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