Causes of fever in Gabonese children: a cross-sectional hospital-based study

Fernandes, José Francisco; Held, Jana; Dorn, Magdalena; Lalremruata, Albert; Schaumburg, Frieder; Alabi, Abraham; Agbanrin, Maradona Daouda; Kokou, Cosme; Ben Adande, Abel; Esen, Meral; Eibach, Daniel; Adegnika, Ayola Akim; Agnandji, Sélidji Todagbé; Lell, Bertrand; Eckerle, Isabella Anne; Henrichfreise, Beate; Hogan, Benedikt; May, Jürgen; Kremsner, Peter Gottfried; Grobusch, Martin Peter; Mordmüller, Benjamin

doi:10.1038/s41598-020-58204-2

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Title		Causes of fever in Gabonese children: a cross-sectional hospital-based study
Authors		Fernandes, José Francisco Held, Jana Dorn, Magdalena Lalremruata, Albert Schaumburg, Frieder Alabi, Abraham Agbanrin, Maradona Daouda Kokou, Cosme Ben Adande, Abel Esen, Meral Eibach, Daniel Adegnika, Ayola Akim Agnandji, Sélidji Todagbé Lell, Bertrand Eckerle, Isabella Anne Henrichfreise, Beate Hogan, Benedikt May, Jürgen Kremsner, Peter Gottfried Grobusch, Martin Peter Mordmüller, Benjamin show all authors [1 - 21]
Published in		Scientific reports. 2020, vol. 10, no. 1, 2080
Abstract		The causes of infections in pediatric populations differ between age groups and settings, particularly in the tropics. Such differences in epidemiology may lead to misdiagnosis and ineffective empirical treatment. Here, we investigated the current spectrum of pathogens causing febrile diseases leading to pediatric hospitalization in Lambaréné, Gabon. From August 2015 to March 2016, we conducted a prospective, cross-sectional, hospital-based study in a provincial hospital. Patients were children ≤ 15 years with fever ≥ 38 °C and required hospitalization. A total of 600 febrile patients were enrolled. Malaria was the main diagnosis found in 52% (311/600) patients. Blood cultures revealed septicemia in 3% (17/593), among them four cases of typhoid fever. The other causes of fever were heterogeneously distributed between both bacteria and viruses. Severe infections identified by Lambaréné Organ Dysfunction Score (LODS) were also most often caused by malaria, but children with danger signs did not have more coinfections than others. In 6% (35/600) of patients, no pathogen was isolated. In Gabon, malaria is still the major cause of fever in children, followed by a bacterial and viral disease. Guidelines for both diagnosis and management should be tailored to the spectrum of pathogens and resources available locally.
Keywords		Child — Child — Preschool — Cross-Sectional Studies — Female — Fever/etiology — Gabon/epidemiology — Hospitals/statistics & numerical data — Humans — Infant — Infections/complications/epidemiology/microbiology/virology — Malaria/complications/epidemiology — Male — Organ Dysfunction Scores — Prospective Studies — Sepsis/complications/epidemiology — Typhoid Fever/complications/epidemiology
Identifiers		DOI: 10.1038/s41598-020-58204-2 PMID: 32034188
Full text		Article (Published version) (1.7 MB) - Free access Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005879/
Research group		Emerging viruses (993)
Citation (ISO format)		FERNANDES, José Francisco et al. Causes of fever in Gabonese children: a cross-sectional hospital-based study. In: Scientific Reports, 2020, vol. 10, n° 1, p. 2080. doi: 10.1038/s41598-020-58204-2 https://archive-ouverte.unige.ch/unige:150079