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Scientific article
Open access
English

Causes of fever in Gabonese children: a cross-sectional hospital-based study

Published inScientific Reports, vol. 10, no. 1, 2080
Publication date2020
Abstract

The causes of infections in pediatric populations differ between age groups and settings, particularly in the tropics. Such differences in epidemiology may lead to misdiagnosis and ineffective empirical treatment. Here, we investigated the current spectrum of pathogens causing febrile diseases leading to pediatric hospitalization in Lambaréné, Gabon. From August 2015 to March 2016, we conducted a prospective, cross-sectional, hospital-based study in a provincial hospital. Patients were children ≤ 15 years with fever ≥ 38 °C and required hospitalization. A total of 600 febrile patients were enrolled. Malaria was the main diagnosis found in 52% (311/600) patients. Blood cultures revealed septicemia in 3% (17/593), among them four cases of typhoid fever. The other causes of fever were heterogeneously distributed between both bacteria and viruses. Severe infections identified by Lambaréné Organ Dysfunction Score (LODS) were also most often caused by malaria, but children with danger signs did not have more coinfections than others. In 6% (35/600) of patients, no pathogen was isolated. In Gabon, malaria is still the major cause of fever in children, followed by a bacterial and viral disease. Guidelines for both diagnosis and management should be tailored to the spectrum of pathogens and resources available locally.

Keywords
  • Child
  • Child
  • Preschool
  • Cross-Sectional Studies
  • Female
  • Fever/etiology
  • Gabon/epidemiology
  • Hospitals/statistics & numerical data
  • Humans
  • Infant
  • Infections/complications/epidemiology/microbiology/virology
  • Malaria/complications/epidemiology
  • Male
  • Organ Dysfunction Scores
  • Prospective Studies
  • Sepsis/complications/epidemiology
  • Typhoid Fever/complications/epidemiology
Affiliation Not a UNIGE publication
Citation (ISO format)
FERNANDES, José Francisco et al. Causes of fever in Gabonese children: a cross-sectional hospital-based study. In: Scientific Reports, 2020, vol. 10, n° 1, p. 2080. doi: 10.1038/s41598-020-58204-2
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Article (Published version)
Identifiers
ISSN of the journal2045-2322
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