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Title

Whole blood serotonin levels in healthy elderly are negatively associated with the functional activity of emotion-related brain regions

Authors
Chocat, Anne
Chételat, Gaël
Poisnel, Géraldine
Klimecki, Olga M.
Collaboration
Published in Biological psychology. 2021, vol. 160, 108051
Abstract Understanding the role of neuromodulators of socio-affective processing is important to ensure psychological wellbeing during older years. Here, we investigated the link between blood serotonin levels and brain and behavioral responses to emotional information in healthy elderly. A priori regions of interest (ROI) were selected due to their role in emotion processing and their dense serotonergic innervation. Correlation analyses were performed between ROI-specific responses to emotional stimuli and whole blood serotonin levels. We found significant negative associations between serotonin and functional activity for the bilateral insula, dorsal anterior cingulate cortex and subgenual gyrus. No association with behavioral measures survived correction for multiple testing. Our results mirror prior pharmacological and genetic work on the link between serotonin and emotional brain reactivity in younger adults. Given the involvement of serotonin in several age-related changes, our study encourages future research to characterize the role of this neuromodulator in emotion processing across the lifespan.
Keywords 5-HTEmotionInsulaOlder adultsSocio-affective video taskSubgenual gyrusDACC.
Identifiers
PMID: 33592271
Full text
Structures
Research groups Affective sciences
Mécanismes cérébraux du comportement et des fonctions cognitives (701)
Project
European Commission: MEDIT-AGEING
Citation
(ISO format)
DEZA, Yacila et al. Whole blood serotonin levels in healthy elderly are negatively associated with the functional activity of emotion-related brain regions. In: Biological Psychology, 2021, vol. 160, p. 108051. doi: 10.1016/j.biopsycho.2021.108051 https://archive-ouverte.unige.ch/unige:149966

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Deposited on : 2021-03-02

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