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Scientific article
English

Transplant oncology in primary and metastatic liver tumor: principles, evidence and opportunities

Published inAnnals of Surgery
Publication date2020
Abstract

Transplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). 1. evolutionary approach to cancer care that includes liver transplantation; 2. elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; 3. exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; 4. extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities.

Keywords
  • Transplant oncology
  • cancer
  • surgery
Citation (ISO format)
SAPISOCHIN, Gonzalo et al. Transplant oncology in primary and metastatic liver tumor: principles, evidence and opportunities. In: Annals of Surgery, 2020. doi: 10.1097/SLA.0000000000004071
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Article (Published version)
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Identifiers
ISSN of the journal0003-4932
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Technical informations

Creation10/29/2020 9:59:00 AM
First validation10/29/2020 9:59:00 AM
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