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Scientific article
English

Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study

Published inMultiple Sclerosis Journal, vol. 27, no. 3, p. 475-478
Publication date2021
Abstract

This prospective multicentre cohort study investigated pregnancy outcomes after fingolimod use for multiple sclerosis during pregnancy. Pregnancy outcomes of 63 fingolimod and 62 interferon-β-exposed pregnancies were compared. Rates of major congenital anomalies (MCA) were 4.8% (2/42) in the fingolimod group versus 2.3% (1/44) in the interferon-β group (odds ratio, 2.2; 95% confidence interval, 0.2-24.6). The adjusted hazard ratio for spontaneous abortion in fingolimod versus interferon-β-exposed pregnancies was 0.6 (95% confidence interval, 0.2-1.8). Further studies are needed to definitely rule out a moderately increased MCA risk after fingolimod exposure during pregnancy.

Keywords
  • Fingolimod
  • Interferon
  • Multiple sclerosis
  • Pregnancy
  • Birth defect
  • Cohort study
Citation (ISO format)
PAULIAT, Emmanuelle et al. Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study. In: Multiple Sclerosis Journal, 2021, vol. 27, n° 3, p. 475–478. doi: 10.1177/1352458520929628
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Article (Published version)
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ISSN of the journal1352-4585
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