Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

van Donge, Tamara; Fuchs, Aline; Leroux, Stéphanie; Pfister, Marc; Rodieux, Frédérique; Atkinson, Andrew; Giannoni, Eric; van den Anker, John; Bielicki, Julia

doi:10.1159/000509751

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Title		Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity
Authors		van Donge, Tamara Fuchs, Aline Leroux, Stéphanie Pfister, Marc Rodieux, Frédérique Atkinson, Andrew Giannoni, Eric van den Anker, John Bielicki, Julia show all authors [1 - 9]
Published in		Neonatology. 2020, vol. 117, no. 5, 619–627
Abstract		Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity.
Keywords		Amoxicillin — Dosing regimen — Model-based simulations — Neonates — Neurotoxicity — Pharmacokinetic/pharmacodynamic targets
Identifiers		DOI: 10.1159/000509751 PMID: 32841941
Full text		Article (Published version) (509 Kb) - Free access Other version: https://www.karger.com/Article/FullText/509751
Structures		Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research group		Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Projects		Autre: Eckenstein-Geigy Foundation Autre: SwissPedDose project supported by the Swiss Federal Public Health Office
Citation (ISO format)		VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751 https://archive-ouverte.unige.ch/unige:149696