

Other version: https://www.karger.com/Article/FullText/509751
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Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity |
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Authors | ![]() | |
Published in | Neonatology. 2020, vol. 117, no. 5, 619–627 | |
Abstract | Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity. | |
Keywords | Amoxicillin — Dosing regimen — Model-based simulations — Neonates — Neurotoxicity — Pharmacokinetic/pharmacodynamic targets | |
Identifiers | DOI: 10.1159/000509751 PMID: 32841941 | |
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![]() ![]() Other version: https://www.karger.com/Article/FullText/509751 |
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Research group | Groupe Desmeules Jules (pharmacologie/toxicologie) (567) | |
Projects | Autre: Eckenstein-Geigy Foundation Autre: SwissPedDose project supported by the Swiss Federal Public Health Office | |
Citation (ISO format) | VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751 https://archive-ouverte.unige.ch/unige:149696 |