Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

van Donge, Tamara; Fuchs, Aline; Leroux, Stéphanie; Pfister, Marc; Rodieux, Frédérique; Atkinson, Andrew; Giannoni, Eric; van den Anker, John; Bielicki, Julia

doi:10.1159/000509751

Scientific article

Open access

English

Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

Contributorsvan Donge, Tamara; Fuchs, Aline; Leroux, Stéphanie; Pfister, Marc; Rodieux, Frédérique; Atkinson, Andrew; Giannoni, Eric; van den Anker, John; Bielicki, Julia

Published inNeonatology, vol. 117, no. 5, p. 619-627

Publication date2020

Abstract

Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity.

Keywords

Amoxicillin
Dosing regimen
Model-based simulations
Neonates
Neurotoxicity
Pharmacokinetic/pharmacodynamic targets

Affiliation

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research group

Groupe Desmeules Jules (pharmacologie/toxicologie) (567)

Funding

Autre - Eckenstein-Geigy Foundation
Autre - SwissPedDose project supported by the Swiss Federal Public Health Office

Citation (ISO format)

VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751

Article (Published version)

CC BY-NC

Identifiers

PID : unige:149696
DOI : 10.1159/000509751
PMID : 32841941

Commercial URLhttps://www.karger.com/Article/FullText/509751

ISSN of the journal1661-7800

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Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

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