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Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

Contributorsvan Donge, Tamara; Fuchs, Aline; Leroux, Stéphanie; Pfister, Marc; Rodieux, Frédérique; Atkinson, Andrew; Giannoni, Eric; van den Anker, John; Bielicki, Julia
Published inNeonatology, vol. 117, no. 5, p. 619-627
Publication date2020
Abstract

Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity.

Keywords
  • Amoxicillin
  • Dosing regimen
  • Model-based simulations
  • Neonates
  • Neurotoxicity
  • Pharmacokinetic/pharmacodynamic targets
Affiliation entities
Research groups
Funding
  • Autre - Eckenstein-Geigy Foundation
  • Autre - SwissPedDose project supported by the Swiss Federal Public Health Office
Citation (ISO format)
VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751
Main files (1)
Article (Published version)
accessLevelPublic CC BY-NC
Identifiers
Additional URL for this publicationhttps://www.karger.com/Article/FullText/509751
Journal ISSN1661-7800
249views
193downloads

Technical informations

Creation26/11/2020 14:16:00
First validation26/11/2020 14:16:00
Update16/03/2023 00:08:29
Status update16/03/2023 00:08:28
Last indexation31/10/2024 21:24:45
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