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Scientific article
Open access
English

Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

Published inNeonatology, vol. 117, no. 5, p. 619-627
Publication date2020
Abstract

Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity.

Keywords
  • Amoxicillin
  • Dosing regimen
  • Model-based simulations
  • Neonates
  • Neurotoxicity
  • Pharmacokinetic/pharmacodynamic targets
Funding
  • Autre - Eckenstein-Geigy Foundation
  • Autre - SwissPedDose project supported by the Swiss Federal Public Health Office
Citation (ISO format)
VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751
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Article (Published version)
Identifiers
ISSN of the journal1661-7800
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43downloads

Technical informations

Creation11/26/2020 2:16:00 PM
First validation11/26/2020 2:16:00 PM
Update time03/16/2023 12:08:29 AM
Status update03/16/2023 12:08:28 AM
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