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Title

Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity

Authors
van Donge, Tamara
Leroux, Stéphanie
Pfister, Marc
Atkinson, Andrew
Giannoni, Eric
van den Anker, John
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Published in Neonatology. 2020, vol. 117, no. 5, 619–627
Abstract Large variability in neonatal amoxicillin dosing recommendations may reflect uncertainty about appropriate efficacy and toxicity targets. The aim of this study was to model efficacious and safe exposure for current neonatal amoxicillin dosing regimens, given a range of assumptions for minimal inhibitory concentration (MIC), targeted %fT > MIC, and potential for aminopenicillin-related neurotoxicity.
Keywords AmoxicillinDosing regimenModel-based simulationsNeonatesNeurotoxicityPharmacokinetic/pharmacodynamic targets
Identifiers
PMID: 32841941
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Structures
Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Projects
Autre: Eckenstein-Geigy Foundation
Autre: SwissPedDose project supported by the Swiss Federal Public Health Office
Citation
(ISO format)
VAN DONGE, Tamara et al. Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. In: Neonatology, 2020, vol. 117, n° 5, p. 619–627. doi: 10.1159/000509751 https://archive-ouverte.unige.ch/unige:149696

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Deposited on : 2021-02-24

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