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Electrophysiological Parameters of the Subthalamic Nucleus During Deep Brain Stimulation Surgery

Master program titleMaster en Médecine Humaine
Defense date2019
Abstract

Microelectrode recordings (MERs) of 37 Parkinson's disease (PD) patients who had subthalamic nucleus (STN) deep brain stimulation (DBS) were located with postoperative image reconstructions. To assess how clinical parameters could predict electrophysiological markers, regressions were performed between preoperative clinical parameters and sensorimotor STN MERs. Wilcoxon-Mann-Whitney tests were used to compare MERs between STN subdivisions, as well as between the STN and surrounding nuclei. Significant associations existed between age and β-oscillations, rigidity and amplitudes of spikes, and bradykinesia and positive phase durations of spikes. In early-onset PD, firing rates were associated with PD duration, the MDS-UPDRS part III score, and bradykinesia. The sensorimotor STN was not electrophysiologically different from the associative/limbic subparts. However, the entire STN differed from other nuclei based on the spike amplitudes. The negative phase of spikes in the STN was shorter than in the thalamus. There were more β-oscillations in the STN than in the substantia nigra.

eng
Keywords
  • Deep brain stimulation
  • subthalamic nucleus
  • neurosurgery
  • electrophysiology
  • Lead-DBS
  • Parkinson's disease
  • STN
  • DBS
  • STN-DBS
Funding
  • Swiss National Science Foundation - Numéro de bourse : 320030-149804
Citation (ISO format)
AL AWADHI, Abdullah. Electrophysiological Parameters of the Subthalamic Nucleus During Deep Brain Stimulation Surgery. 2019.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:149677
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