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The underlying mechanisms of mismatch negativity response in 22q11.2 deletion syndrome

Defense Thèse de doctorat : Univ. Genève et Lausanne, 2020 - Neur. 287 - 2020/11/24
Abstract The 22q11.2 Deletion Syndrome (22q11.2 DS), one of the highest genetic risk for the development of schizophrenia, offers a unique opportunity to understand neurobiological and functional changes preceding the onset of the psychotic illness. In the search for biomarkers, the altered auditory function, such as reduced auditory mismatch negativity has been proposed as a reliable marker for schizophrenia. To explore the general pattern of auditory sensory processing and its underlying mechanisms, two studies were designed hypothesising schizophrenia-like functional auditory abnormalities in 22q11.2DS. Interestingly, we observe abnormal development of auditory functioning from childhood to adolescence in non-psychotic 22q11.2 deletion carriers as compared to typically developing individuals that is not associated with lower IQ or psychotic symptoms and is unrelated to structural changes measured along the auditory pathways. Therefore, our results might reveal impaired auditory emotion recognition, a key feature of social cognition, and abnormal neuromodulation of bottom-up op-down information processing.
Keywords 22q11.2 Deletion SyndromeAuditory processingPsychosisAuditory mismach negativity response
URN: urn:nbn:ch:unige-1496731
Note Thèse de doctorat des Universités de Genève et Lausanne
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Swiss National Science Foundation: The Synaptic Bases of Mental Diseases grant number 51NF40 – 185897 to Professor Christoph Michel.
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CANTONAS, Lucia-Manuela. The underlying mechanisms of mismatch negativity response in 22q11.2 deletion syndrome. Université de Genève. Thèse, 2020. doi: 10.13097/archive-ouverte/unige:149673 https://archive-ouverte.unige.ch/unige:149673

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Deposited on : 2021-02-24

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