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Scientific article
English

Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine

Published inExperimental Hematology, vol. 35, no. 7, p. 1140-1152
Publication date2007
Abstract

We have evaluated T-cell reconstitution and reactivity in patients receiving nonmyeloablative haploidentical hematopoietic cell transplantation (HCT) protocols involving an anti-CD2 monoclonal antibody (MEDI 507) to treat chemorefractory hematopoietic malignancies.

Keywords
  • Antibodies, Monoclonal/pharmacology
  • Antibodies, Monoclonal, Humanized
  • Antigens, CD/analysis
  • Antigens, Differentiation/analysis
  • CD2 Antigens/immunology
  • CTLA-4 Antigen
  • Forkhead Transcription Factors/analysis
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Interferon-gamma/genetics
  • T-Lymphocytes, Regulatory/physiology
  • Transforming Growth Factor beta/genetics
  • Transplantation Chimera
  • Vidarabine/analogs & derivatives/pharmacology
Affiliation Not a UNIGE publication
Citation (ISO format)
SHAFFER, Juanita et al. Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. In: Experimental Hematology, 2007, vol. 35, n° 7, p. 1140–1152. doi: 10.1016/j.exphem.2007.03.018
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Article (Published version)
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Identifiers
ISSN of the journal0301-472X
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