Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Petersdorf, Effie W; Carrington, Mary; O'hUigin, Colm; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Gooley, Ted; Horowitz, Mary; Hsu, Katharine; Madrigal, J Alejandro; Maiers, Martin J; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen R; Villard, Jean; Stevenson, Phil; International Histocompatibility Working Group in Hematopoietic Cell Transplantation

doi:10.1016/S2352-3026(19)30208-X

Scientific article

English

Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

ContributorsPetersdorf, Effie W; Carrington, Mary; O'hUigin, Colm; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Gooley, Ted; Horowitz, Mary; Hsu, Katharine; Madrigal, J Alejandro; Maiers, Martin J; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen R; Villard, Jean; Stevenson, Phil; International Histocompatibility Working Group in Hematopoietic Cell Transplantation

Published inThe Lancet. Haematology, vol. 7, no. 1, p. e50-e60

Publication date2020

Abstract

The success of unrelated haemopoietic cell transplantation (HCT) is limited by graft-versus-host disease (GVHD), which is the main post-transplantation challenge when HLA-matched donors are unavailable. A sequence dimorphism in exon 1 of HLA-B gives rise to leader peptides containing methionine (Met; M) or threonine (Thr; T), which differentially influence natural killer and T-cell alloresponses. The main aim of the study was to evaluate the role of the leader dimorphism in GVHD after HLA-B-mismatched unrelated HCT.

Keywords

Adolescent
Adult
Exons/genetics
Female
Graft vs Host Disease/genetics/immunology
HLA-B Antigens/genetics
Hematopoietic Stem Cell Transplantation/methods
Histocompatibility
Histocompatibility Testing
Humans
Male
Middle Aged
Multivariate Analysis
Retrospective Studies

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Transplantation immunologie et osteoimmunologie (561)

Funding

Swiss National Science Foundation - New insights in the immunogenetics of haematopoietic stem cell transplantation [310030_173237]

Citation (ISO format)

PETERSDORF, Effie W et al. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study. In: The Lancet. Haematology, 2020, vol. 7, n° 1, p. e50–e60. doi: 10.1016/S2352-3026(19)30208-X

Article (Published version)

Identifiers

PID : unige:149590
DOI : 10.1016/S2352-3026(19)30208-X
PMID : 31669248

Commercial URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948919/pdf/nihms-1546140.pdf

ISSN of the journal2352-3026

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Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

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