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A self-assembling porous and injectable biomaterial for regenerative medicine

Naveiras, Olaia
Defense Thèse de doctorat : Univ. Genève, 2020 - Sc. Vie 83 - 2020/10/26
Abstract Biomaterials are key players in the technology-driven field of regenerative medicine. Traditionally established to provide mechanical function or to improve delivery of pharmacological substances aiding the tissue repair, they are increasingly investigated as a support for emergent cell-based therapy. In this thesis, we give to the reader a general overview of the journey from in silico conception to the preclinical applications of a new biomaterial. Based on elastic porous and irregular particles, this biomaterial allows for injection through thin needles while being able to rearrange and interlock to reform the solid cohesive initial structure. We also propose potential applications for this biomaterial ranging from cell transplantation to spontaneous soft tissue reconstruction. The versatility of this biomaterial has the potential to benefit a wide range of clinical application in the field of regenerative medicine.
Keywords BiomaterialMeta-biomaterialRegenerative medicineIn silico biomaterial conceptionMechanical characterisationSoft tissue reconstructionEctopic bone marrowGlymphatic brain-on-a-chip
URN: urn:nbn:ch:unige-1495132
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Thesis (4.4 MB) - public document Free access
Research group Groupe Thomas Braschler (970)
Swiss National Science Foundation: PP00P2_163684
Swiss National Science Foundation: PZ00P2_161347
(ISO format)
BONINI, Fabien. A self-assembling porous and injectable biomaterial for regenerative medicine. Université de Genève. Thèse, 2020. doi: 10.13097/archive-ouverte/unige:149513 https://archive-ouverte.unige.ch/unige:149513

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Deposited on : 2021-02-22

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