Polypharmacy and the use of potentially inappropriate medications (PIMs) are frequent prescribing problems among nursing home (NH) residents. Deprescribing has recently emerged as a powerful tool to reduce both problems. The Opportunities and Limits to Deprescribing in Nursing Homes (OLD-NH) trialled two complementary deprescribing interventions in the NHs of Vaud and Fribourg, one at the NH level (QC-DeMo), the other at the resident level (IDeI). Fifty-six NHs took part in the QC-DeMo trial, with 27 randomised to the intervention group. There was a strong trend towards a reduction in PIMs use in the intervention group, and the use of some PIMs classes decreased significantly. The IDeI trial recruited 58 NH residents, and showed that this intervention successfully reduced the doses of PIMs used. No adverse effects were seen on death, hospitalisations, falls, and physical restraints use, but a trend towards a decrease in quality of life was noted.