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Scientific article
English

Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

Published inNeurology, vol. 80, no. 11, p. 1048-1056
Publication date2013
Abstract

The current model of Alzheimer disease (AD) stipulates that brain amyloidosis biomarkers turn abnormal earliest, followed by cortical hypometabolism, and finally brain atrophy ones. The aim of this study is to provide clinical evidence of the model in patients with mild cognitive impairment (MCI).

Keywords
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/cerebrospinal fluid/diagnosis/pathology
  • Amyloid beta-Peptides/cerebrospinal fluid
  • Atrophy
  • Biomarkers/cerebrospinal fluid
  • Brain/pathology
  • Cognitive Dysfunction/cerebrospinal fluid/diagnosis/pathology
  • Dementia/diagnosis/pathology
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Peptide Fragments/cerebrospinal fluid
  • Predictive Value of Tests
  • tau Proteins/cerebrospinal fluid
Affiliation Not a UNIGE publication
Citation (ISO format)
PRESTIA, Annapaola et al. Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease. In: Neurology, 2013, vol. 80, n° 11, p. 1048–1056. doi: 10.1212/WNL.0b013e3182872830
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0028-3878
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