Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

Prestia, Annapaola; Caroli, Anna; van der Flier, Wiesje M; Ossenkoppele, Rik; Van Berckel, Bart; Barkhof, Frederik; Teunissen, Charlotte E; Wall, Anders E; Carter, Stephen F; Schöll, Michael; Choo, Il Han; Nordberg, Agneta; Scheltens, Philip; Frisoni, Giovanni

doi:10.1212/WNL.0b013e3182872830

Scientific article

English

Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

ContributorsPrestia, Annapaola; Caroli, Anna; van der Flier, Wiesje M; Ossenkoppele, Rik; Van Berckel, Bart; Barkhof, Frederik; Teunissen, Charlotte E; Wall, Anders E; Carter, Stephen F; Schöll, Michael; Choo, Il Han; Nordberg, Agneta; Scheltens, Philip; Frisoni, Giovanni

Published inNeurology, vol. 80, no. 11, p. 1048-1056

Publication date2013

Abstract

The current model of Alzheimer disease (AD) stipulates that brain amyloidosis biomarkers turn abnormal earliest, followed by cortical hypometabolism, and finally brain atrophy ones. The aim of this study is to provide clinical evidence of the model in patients with mild cognitive impairment (MCI).

Keywords

Aged
Aged, 80 and over
Alzheimer Disease/cerebrospinal fluid/diagnosis/pathology
Amyloid beta-Peptides/cerebrospinal fluid
Atrophy
Biomarkers/cerebrospinal fluid
Brain/pathology
Cognitive Dysfunction/cerebrospinal fluid/diagnosis/pathology
Dementia/diagnosis/pathology
Disease Progression
Female
Follow-Up Studies
Humans
Male
Middle Aged
Peptide Fragments/cerebrospinal fluid
Predictive Value of Tests
tau Proteins/cerebrospinal fluid

Affiliation entities

Not a UNIGE publication

Research groups

Troubles de mémoire et maladie d'Alzeimer (935)

Citation (ISO format)

PRESTIA, Annapaola et al. Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease. In: Neurology, 2013, vol. 80, n° 11, p. 1048–1056. doi: 10.1212/WNL.0b013e3182872830

Article (Published version)

Identifiers

PID : unige:149476
DOI : 10.1212/WNL.0b013e3182872830
PMID : 23390179

Additional URL for this publicationhttps://n.neurology.org/content/80/11/1048

Journal ISSN0028-3878

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Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

The current model of Alzheimer disease (AD) stipulates that brain amyloidosis biomarkers turn abnormal earliest, followed by cortical hypometabolism, and finally brain atrophy ones. The aim of this study is to provide clinical evidence of the model in patients with mild cognitive impairment (MCI).

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