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Title

Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies

Authors
Molinuevo, José Luis
Barkhof, Frederik
Berkhof, Johannes
Delrieu, Julien
Dubois, Bruno
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Published in Alzheimer's & Dementia. 2020, vol. 16, no. 10, p. 1457-1468
Abstract Empirical evidence suggests that a fair proportion of dementia cases are preventable, that some preventive actions can be taken immediately, and others may soon be implemented. Primary prevention may target cognitively normal persons with modifiable risk factors through lifestyle and multiple domain interventions (including general cardiovascular health). While the effect on individuals may be modest, it might have a large societal impact by decreasing overall dementia incidence by up to 35%. Secondary prevention will target cognitively normal persons at high risk of dementia due to Alzheimer's disease pathology with future anti-amyloid, anti-tau, or other drugs. This approach is likely to have major benefits to both individuals and society. Memory clinics will need structural and functional changes to adapt to novel technologies and increased patients' demands, and brand-new services may need to be developed with specific skills on risk profiling, risk communication, and personalized risk reduction plans.
Identifiers
PMID: 32815289
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Other version: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12132
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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FRISONI, Giovanni et al. Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies. In: Alzheimer's & Dementia, 2020, vol. 16, n° 10, p. 1457-1468. doi: 10.1002/alz.12132 https://archive-ouverte.unige.ch/unige:149341

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Deposited on : 2021-02-16

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