UNIGE document Scientific Article
previous document  unige:149190  next document
add to browser collection
Title

Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Authors
Aeschbacher, Stefanie
Blum, Steffen
Meyre, Pascal B.
Coslovsky, Michael
Vischer, Annina S.
Sinnecker, Tim
Rodondi, Nicolas
Beer, Jürg H.
show hidden authors show all authors [1 - 21]
CollaborationWith : Auberson, Chloé / Ceylan, Selinda / Doerpfeld, Simone / Girod, Marc / Hennings, Elisa / Krisai, Philipp / Monsch, Andreas U. / Muller, Christian / Springer, Anne / Voellmin, Gian / Aujesky, Drahomir / Fischer, Urs / Fuhrer, Juerg / Jung, Simon / Mattle, Heinrich / Adam, Luise / Elodie Aubert, Carole / Feller, Martin / Loewe, Axel / Schneider, Claudio / Flückiger, Tanja / Groen, Cindy / Ehrsam, Lukas / Hellrigl, Sven / Nuoffer, Alexandra / Rakovic, Damiana / Schwab, Nathalie / Wenger, Rylana / Müller, Andreas / Beynon, Christopher / Dillier, Roger / Deubelbeiss, Michèle / Eberli, Franz / Franzini, Christine / Juchli, Isabel / Liedtke, Claudia / Nadler, Jacqueline / Obst, Thayze / Roth, Jasmin / Schlomowitsch, Fiona / Schneider, Xiaoye / Studerus, Katrin / Tynan, Noreen / Weishaupt, Dominik / Fontana, Simone / Kuest, Silke / Scheuch, Karin / Hischier, Denise / Bonetti, Nicole / Grau, Alexandra / Villinger, Jonas / Laube, Eva / Baumgartner, Philipp / Filipovic, Mark / Frick, Marcel / Montrasio, Giulia / Leuenberger, Stefanie / Rutz, Franziska / Moccetti, Tiziano / Auricchio, Angelo / Anesini, Adriana / Camporini, Cristina / Conte, Giulio / Luce Caputo, Maria / Regoli, François / Ammann, Peter / Brenner, Roman / Altmann, David / Gemperle, Michaela / Hayoz, Daniel / Firmann, Mathieu / Foucras, Sandrine / Rime, Martine / Kobza, Richard / Berte, Benjamin / Justi, Virgina / Kellner-Weldon, Frauke / Mehmann, Brigitta / Meier, Sonja / Roth, Myriam / Ruckli-Kaeppeli, Andrea / Russi, Ian / Schmidt, Kai / Young, Mabelle / Zbinden, Melanie / Frangi-Kultalahti, Jane / Pin, Anica / Shah, Dipen / Ehret, Georg Benedikt / Gallet, Hervé / Guillermet, Elise / Lazeyras, François / Lövblad, Karl-Olof / Perret, Patrick / Tavel, Philippe / Teres Castillo, Cheryl / Schläpfer, Jürg / Lauriers, Nathalie / Méan, Marie / Salzmann, Sandrine / Stephan, Frank-Peter / Grêt, Andrea / Novak, Jan / Vitelli, Sandra / Di Valentino, Marcello / Gallino, Augusto / Witassek, Fabienne / Schwenkglenks, Matthias / Altermatt, Anna / Amann, Michael / Huber, Petra / Ruberte, Esther / Zuber, Vanessa / Benkert, Pascal / Dutilh, Gilles / Markovic, Milica / Neuschwander, Pia / Simon, Patrick / Schmid, Ramun
Published in Hypertension. 2020, vol. 77, no. 2, p. 662-671
Abstract The association of blood pressure (BP) and hypertension with the presence of different types of brain lesions in patients with atrial fibrillation is unclear. BP values were obtained in a multicenter cohort of patients with atrial fibrillation. Systolic and diastolic BP was categorized in predefined groups. All patients underwent brain magnetic resonance imaging and neurocognitive testing. Brain lesions were classified as large noncortical or cortical infarcts, small noncortical infarcts, microbleeds, or white matter lesions. White matter lesions were graded according to the Fazekas scale. Overall, 1738 patients with atrial fibrillation were enrolled in this cross-sectional analysis (mean age, 73 years, 73% males). Mean BP was 135/79 mm Hg, and 67% of participants were taking BP-lowering treatment. White matter lesions Fazekas ≥2 were found in 54%, large noncortical or cortical infarcts in 22%, small noncortical infarcts in 21%, and microbleeds in 22% of patients, respectively. Compared with patients with systolic BP <120 mm Hg, the adjusted odds ratios (95% CI) for Fazekas≥2 was 1.25 (0.94-1.66), 1.41 (1.03-1.93), and 2.54 (1.65-3.95) among patients with systolic BP of 120 to 140, 140 to 160, and ≥160 mm Hg (P for linear trend<0.001). Per 5 mm Hg increase in systolic and diastolic BP, the adjusted β-coefficient (95% CI) for log-transformed white matter lesions was 0.04 (0.02-0.05), P<0.001 and 0.04 (0.01-0.06), P=0.004. Systolic BP was associated with small noncortical infarcts (odds ratios [95% CI] per 5 mm Hg 1.05 [1.01-1.08], P=0.006), microbleeds were associated with hypertension, but large noncortical or cortical infarcts were not associated with BP or hypertension. After multivariable adjustment, BP and hypertension were not associated with neurocognitive function. Among patients with atrial fibrillation, BP is strongly associated with the presence and extent of white matter lesions, but there is no association with large noncortical or cortical infarcts. Registration: https://clinicaltrials.gov/ct2/show/NCT02105844
Keywords Atrial fibrillationBlood pressureBrainMagnetic resonance imagingWhite matter
Identifiers
PMID: 33356398
Full text
Structures
Research group Ischémie cérébrale et connectivité (801)
Project
Swiss National Science Foundation: 33CS30_148474, 33CS30_177520, 32473B_176178
Citation
(ISO format)
AESCHBACHER, Stefanie et al. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation. In: Hypertension, 2020, vol. 77, n° 2, p. 662-671. doi: 10.1161/HYPERTENSIONAHA.120.16025 https://archive-ouverte.unige.ch/unige:149190

237 hits

54 downloads

Update

Deposited on : 2021-02-15

Export document
Format :
Citation style :