European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4–G5D

Evenepoel, Pieter; Cunningham, John; Ferrari, Serge Livio; Haarhaus, Mathias; Javaid, Muhammad Kassim; Lafage-Proust, Marie-Hélène; Prieto-Alhambra, Daniel; Torres, Pablo Ureña; Cannata-Andia, Jorge

doi:10.1093/ndt/gfaa192

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Title		European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4–G5D
Authors		Evenepoel, Pieter Cunningham, John Ferrari, Serge Livio Haarhaus, Mathias Javaid, Muhammad Kassim Lafage-Proust, Marie-Hélène Prieto-Alhambra, Daniel Torres, Pablo Ureña Cannata-Andia, Jorge show all authors [1 - 9]
Collaboration		European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA, and the committee of Scientific Advisors and National Societies of the IOF
Published in		Nephrology Dialysis Transplantation. 2021, vol. 36, no. 1, p. 42-59
Abstract		Controlling the excessive fracture burden in patients with chronic kidney disease (CKD) Stages G4–G5D remains an impressive challenge. The reasons are 2-fold. First, the pathophysiology of bone fragility in patients with CKD G4–G5D is complex and multifaceted, comprising a mixture of age-related (primary male/postmenopausal), drug-induced and CKD-related bone abnormalities. Second, our current armamentarium of osteoporosis medications has not been developed for, or adequately studied in patients with CKD G4–G5D, partly related to difficulties in diagnosing osteoporosis in this specific setting and fear of complications. Doubts about the optimal diagnostic and therapeutic approach fuel inertia in daily clinical practice. The scope of the present consensus paper is to review and update the assessment and diagnosis of osteoporosis in patients with CKD G4-G5D and to discuss the therapeutic interventions available and the manner in which these can be used to develop management strategies for the prevention of fragility fracture. As such, it aims to stimulate a cohesive approach to the management of osteoporosis in patients with CKD G4–G5D to replace current variations in care and treatment nihilism.
Keywords		Bone mineral density — Chronic renal insufficiency — CKD-MBD — Mineral metabolism — Renal osteodystrophy
Identifiers		DOI: 10.1093/ndt/gfaa192 PMID: 33098421
Full text		Article (Published version) (615 Kb) - Limited access to UNIGE Other version: https://academic.oup.com/ndt/article/36/1/42/5938134
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Génétique des ostéoporoses (544)
Citation (ISO format)		EVENEPOEL, Pieter et al. European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4–G5D. In: Nephrology Dialysis Transplantation, 2021, vol. 36, n° 1, p. 42-59. doi: 10.1093/ndt/gfaa192 https://archive-ouverte.unige.ch/unige:149105