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Scientific article
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English

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Published inNPJ Vaccines, vol. 5, 32
Errata
  • The original version of this Article contained an error in the spelling of a member of the VSV-EBOVAC and VSV-EBOPLUS Consortia, Ali M. Harandi, which was incorrectly given as Ali Harandi.
  • DOI : 10.1038/s41541-020-00244-w
  • PMID : 33083028
Publication date2020-04-14
Abstract

The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.

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Citation (ISO format)
PEJOSKI, David et al. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. In: NPJ Vaccines, 2020, vol. 5, p. 32. doi: 10.1038/s41541-020-0179-4
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ISSN of the journal2059-0105
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