Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Pejoski, David; De Rham, Casimir; Martinez Murillo, Paola Andréa; Santoro, Francesco; Auderset, Floriane; Medaglini, Donata; Pozzi, Gianni; Vono, Maria; Lambert, Paul Henri; Csaki Huttner, Angela; Haks, Mariëlle C; Ottenhoff, Tom H M; Villard, Jean; Siegrist, Claire-Anne; VEBCON consortium; VSV-EBOVAC consortium; VSV-EBOPLUS consortium

doi:10.1038/s41541-020-0179-4

Scientific article

English

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Errata

The original version of this Article contained an error in the spelling of a member of the VSV-EBOVAC and VSV-EBOPLUS Consortia, Ali M. Harandi, which was incorrectly given as Ali Harandi.
DOI : 10.1038/s41541-020-00244-w
PMID : 33083028

ContributorsPejoski, David; De Rham, Casimir; Martinez Murillo, Paola Andréa; Santoro, Francesco; Auderset, Floriane; Medaglini, Donata; Pozzi, Gianni; Vono, Maria; Lambert, Paul Henri; Csaki Huttner, Angela; Haks, Mariëlle C; Ottenhoff, Tom H M; Villard, Jean; Siegrist, Claire-Anne; VEBCON consortium; VSV-EBOVAC consortium; VSV-EBOPLUS consortium

Published inNPJ Vaccines, vol. 5, 32

Publication date2020-04-14

Abstract

The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.

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Citation (ISO format)

PEJOSKI, David et al. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. In: NPJ Vaccines, 2020, vol. 5, p. 32. doi: 10.1038/s41541-020-0179-4