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Title

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
Authors
Pejoski, David
De Rham, Casimir
Martinez Murillo, Paola Andréa
Santoro, Francesco
Auderset, Floriane
Medaglini, Donata
Pozzi, Gianni
Vono, Maria
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Collaboration
Published in npj vaccines. 2020, vol. 5, 32
Abstract The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.
Identifiers
PMID: 32337075
Full text
Article (Published version) (3.4 MB) - public document Free access
Supplemental data (663 Kb) - public document Free access
Dataset: https://zenodo.org/record/3415147#.YCY4VefjKMo
Dataset: https://figshare.com/articles/dataset/cytometry_data/11886678/1
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups Centre de vaccinologie et d'immunologie néonatale (177)
Transplantation immunologie et osteoimmunologie (561)
Citation
(ISO format) 		PEJOSKI, David et al. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. In: NPJ Vaccines, 2020, vol. 5, p. 32. doi: 10.1038/s41541-020-0179-4 https://archive-ouverte.unige.ch/unige:149076

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Deposited on : 2021-02-12

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