en
Scientific article
English

Metastatic Hibernomas in Transgenic Mice Expressing an α-Amylase-SV40 T Antigen Hybrid Gene

Published inScience, vol. 244, p. 460-463
Publication date1989
Abstract

Mice transgenic for a hybrid gene containing the liver promoter of the mouse α-amylase gene (Amy-1a) fused to the SV40 tumor antigen coding region unexpectedly developed malignant brown adipose tissue tumors (malignant hibernomas). Expression of the α-amylase gene had previously been thought to be confined to the liver, parotid, and pancreas; however, analysis of white and brown adipose tissue from nontransgenic mice revealed expression of the endogenous Amy-1a gene in these tissues. Gene constructs driven by the Amy-1a liver promoter thus provide a means of targeting gene expression to the adipocyte cell lineage in transgenic mice. Moreover, the high frequency of metastases in the liver, lungs, spleen, heart, and adrenals of these mice provides an experimental system in which to study the development of disseminated malignancy.

Citation (ISO format)
FOX, Niles et al. Metastatic Hibernomas in Transgenic Mice Expressing an α-Amylase-SV40 T Antigen Hybrid Gene. In: Science, 1989, vol. 244, p. 460–463.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
  • PID : unige:148889
ISSN of the journal0036-8075
121views
0downloads

Technical informations

Creation02/01/2021 2:15:00 PM
First validation02/01/2021 2:15:00 PM
Update time03/16/2023 12:01:39 AM
Status update03/16/2023 12:01:39 AM
Last indexation01/17/2024 12:24:29 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack