Polymorphisme des HLA loci de classe l, HL A-A, -B et -C, dans la population Mandenka du Sénégal Oriental (Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal)

Dard, Patricia Nathalie; Schreiber, Y.; Excoffier, Laurent Georges Louis; Sanchez-Mazas, Alicia; Shi-Isaac, X.; Epelbouin, A.; Langaney, André; Jeannet, Michel

Scientific article

French

Polymorphisme des HLA loci de classe l, HL A-A, -B et -C, dans la population Mandenka du Sénégal Oriental (Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal)

ContributorsDard, Patricia Nathalie; Schreiber, Y.; Excoffier, Laurent Georges Louis; Sanchez-Mazas, Alicia; Shi-Isaac, X.; Epelbouin, A.; Langaney, André; Jeannet, Michel

Published inComptes rendus de l'Académie des sciences. Série 3, Sciences de la vie, vol. 314, no. 13, p. 573-578

Publication date1992

Abstract

A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for the three loci A, B, and C are respectively 0.884, 0.944 and 0.829. The Mandenkalu allelic frequencies are close to that found in other sub-Saharan populations. They show, however, some peculiarities like the occurrence of the Bw 56 allele and the high frequencies of both B5 and B35.

Keywords

Allele
Human genetics
Phenotype
Senegal Polymorphism
Mandenka

Affiliation entities

Research groups

Unité d'anthropologie

Citation (ISO format)

DARD, Patricia Nathalie et al. Polymorphisme des HLA loci de classe l, HL A-A, -B et -C, dans la population Mandenka du Sénégal Oriental (Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal). In: Comptes rendus de l’Académie des sciences. Série 3, Sciences de la vie, 1992, vol. 314, n° 13, p. 573–578.

Article (Published version)

Identifiers

PID : unige:14854
PMID : 1393737

Journal ISSN0764-4469

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Polymorphisme des HLA loci de classe l, HL A-A, -B et -C, dans la population Mandenka du Sénégal Oriental (Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal)

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