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BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots

Crook, Ashley D
Willoughby, Andrew C
Hazak, Ora
VanDerMolen, Kylie R
Soyars, Cara L
Cattaneo, Pietro
Clark, Natalie M
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Published in Proceedings of the National Academy of Sciences of the United States of America. 2020, vol. 117, no. 51, p. 32750-32756
Abstract Cell division is often regulated by extracellular signaling networks to ensure correct patterning during development. In Arabidopsis, the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates CYCLIND6;1 (CYCD6;1) to drive formative divisions during root ground tissue development. Here, we show plasma-membrane-localized BARELY ANY MERISTEM1/2 (BAM1/2) family receptor kinases are required for SHR-dependent formative divisions and CYCD6;1 expression, but not SHR-dependent ground tissue specification. Root-enriched CLE ligands bind the BAM1 extracellular domain and are necessary and sufficient to activate SHR-mediated divisions and CYCD6;1 expression. Correspondingly, BAM-CLE signaling contributes to the restriction of formative divisions to the distal root region. Additionally, genetic analysis reveals that BAM-CLE and SHR converge to regulate additional cell divisions outside of the ground tissues. Our work identifies an extracellular signaling pathway regulating formative root divisions and provides a framework to explore this pathway in patterning and evolution.
PMID: 33288706/
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Article (Published version) (1.4 MB) - public document Free access
Research group Groupe Hothorn
Swiss National Science Foundation: 31CP30_180213
Autre: Howard Hughes Medical Institute International Research Scholar program
(ISO format)
CROOK, Ashley D et al. BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots. In: Proceedings of the National Academy of Sciences, 2020, vol. 117, n° 51, p. 32750-32756. doi: 10.1073/pnas.2018565117 https://archive-ouverte.unige.ch/unige:148436

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Deposited on : 2021-02-02

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