BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots

Crook, Ashley D; Willoughby, Andrew C; Hazak, Ora; Okuda, Satohiro; VanDerMolen, Kylie R; Soyars, Cara L; Cattaneo, Pietro; Clark, Natalie M; Sozzani, Rosangela; Hothorn, Michael; Hardtke, Christian S; Nimchuk, Zachary L

doi:10.1073/pnas.2018565117

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots
Authors		Crook, Ashley D Willoughby, Andrew C Hazak, Ora Okuda, Satohiro VanDerMolen, Kylie R Soyars, Cara L Cattaneo, Pietro Clark, Natalie M Sozzani, Rosangela Hothorn, Michael Hardtke, Christian S Nimchuk, Zachary L show all authors [1 - 12]
Published in		Proceedings of the National Academy of Sciences of the United States of America. 2020, vol. 117, no. 51, p. 32750-32756
Abstract		Cell division is often regulated by extracellular signaling networks to ensure correct patterning during development. In Arabidopsis, the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates CYCLIND6;1 (CYCD6;1) to drive formative divisions during root ground tissue development. Here, we show plasma-membrane-localized BARELY ANY MERISTEM1/2 (BAM1/2) family receptor kinases are required for SHR-dependent formative divisions and CYCD6;1 expression, but not SHR-dependent ground tissue specification. Root-enriched CLE ligands bind the BAM1 extracellular domain and are necessary and sufficient to activate SHR-mediated divisions and CYCD6;1 expression. Correspondingly, BAM-CLE signaling contributes to the restriction of formative divisions to the distal root region. Additionally, genetic analysis reveals that BAM-CLE and SHR converge to regulate additional cell divisions outside of the ground tissues. Our work identifies an extracellular signaling pathway regulating formative root divisions and provides a framework to explore this pathway in patterning and evolution.
Identifiers		DOI: 10.1073/pnas.2018565117 PMID: 33288706/
Full text		Article (Published version) (1.4 MB) - Free access
Structures		Faculté des sciences / Section de biologie / Département des sciences végétales
Research group		Groupe Hothorn
Projects		Swiss National Science Foundation: 31CP30_180213 Autre: Howard Hughes Medical Institute International Research Scholar program
Citation (ISO format)		CROOK, Ashley D et al. BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots. In: Proceedings of the National Academy of Sciences, 2020, vol. 117, n° 51, p. 32750-32756. doi: 10.1073/pnas.2018565117 https://archive-ouverte.unige.ch/unige:148436