en
Doctoral thesis
Open access
English

Digital Blood

ContributorsKotsalos, Christos
Defense date2020-12-15
Abstract

This thesis aims at building high-fidelity models for the simulation of blood at both the microscopic and the macroscopic scales. Our work focuses on creating a digital replica of human blood through various tools of multi-scale/multi-physics nature, and on contributing novel pieces towards the realisation of a digital lab. We then use these tools for investigating cases that span from fundamental research to problems of clinical relevance. Focal point has been the understanding of the underlying mechanisms of platelet transport. For this, we followed a bottom-up approach, i.e. started from fully resolved blood flow simulations (microscopic scale) and moved towards calibrated stochastic models (macroscopic scale). Our results help clarify platelet transport physics, leading to more accurate modelling and design of PLT function tests (e.g. Impact-R device). Given the limited prognostic capacity of these tests, we believe that our models could lead in next generation tests with higher clinical relevance/readiness.

eng
Funding
  • European Commission - grant agreement No 675451 (CompBioMed project) & grant agreement No 823712 (CompBioMed2 project)
Citation (ISO format)
KOTSALOS, Christos. Digital Blood. 2020. doi: 10.13097/archive-ouverte/unige:148411
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Thesis
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Technical informations

Creation01/25/2021 1:40:00 PM
First validation01/25/2021 1:40:00 PM
Update time03/15/2023 11:57:29 PM
Status update03/15/2023 11:57:28 PM
Last indexation01/29/2024 10:29:31 PM
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