The transportation of dangerous goods (TDG) remains one of the main challenges to manage for the stakeholder who provides such services. The process of TDG is complicated by itself due to the fact that several local and international regulation frameworks should be considered. The process of TDG enlists several difficulties for the stakeholders, in managing, monitoring, and validation the process of TDG with the regulation framework. This paper aims at presenting a conceptual and technical approach for designing and developing a sustainable solution for the process of TDG in compliance with the regulatory framework.