en
Scientific article
Open access
English

New data for AG haplotype frequencies in Caucasoid populations and selective neutrality of the AG polymorphism

Published inHuman biology, vol. 66, no. 1, p. 27-48
Publication date1994
Abstract

We present the results of AG antigen typings of three Caucasoid population samples: Lebanese, Tunisians, and Finns. AG haplotype frequencies estimated by maximum-likelihood methods are compared with the frequencies observed in 13 world populations previously tested for AG specificities by computing a genetic distance matrix used in a multivariate analysis. A high degree of polymorphism characterizes the three samples, with 10 haplotypes detected in the Lebanese and 11 haplotypes detected in the Tunisians and Finns; high heterozygosity levels are also present in the three populations. The genetic distance analysis shows that the three populations possess a genetic structure intermediate between those observed in sub-Saharan Africans and in Caucasoids from the Near East and India. This tight correspondence between AG differentiation and geography is confirmed by a highly significant correlation coefficient found between genetic and geographic distances computed worldwide, suggesting that an isolation by distance model of evolution applies to the AG system. The Ewens-Watterson test for selective neutrality on all world populations tested for AG specificities also supports the hypothesis that the AG system behaves like a neutral polymorphism. Overall, the AG differentiation pattern appears to be close to the patterns observed for other serological polymorphisms, such as RH, GM, and HLA, whose evolutionary mechanisms are also discussed.

Keywords
  • Human genetics
  • Europe
  • Lebanon
  • Tunisia
  • Antigens
  • Haplotype
  • Phenotype
  • Phylogeny
  • Genetic polymorphism
  • Multivariate analysis
Citation (ISO format)
SANCHEZ-MAZAS, Alicia et al. New data for AG haplotype frequencies in Caucasoid populations and selective neutrality of the AG polymorphism. In: Human biology, 1994, vol. 66, n° 1, p. 27–48.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0018-7143
725views
148downloads

Technical informations

Creation03/18/2011 4:38:00 PM
First validation03/18/2011 4:38:00 PM
Update time03/14/2023 4:14:31 PM
Status update03/14/2023 4:14:31 PM
Last indexation01/15/2024 10:15:44 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack