Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music

James, Clara; Altenmüller, Eckart; Kliegel, Matthias; Krüger, Tillmann H.C.; Van De Ville, Dimitri; Worschech, Florian; Abdili, Laura; Scholz, Daniel S.; Jünemann, Kristin; Hering, Alexandra; Grouiller, Frédéric; Sinke, Christopher; Marie, Damien

doi:10.1186/s12877-020-01761-y

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Title		Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music
Authors		James, Clara Altenmüller, Eckart Kliegel, Matthias Krüger, Tillmann H.C. Van De Ville, Dimitri Worschech, Florian Abdili, Laura Scholz, Daniel S. Jünemann, Kristin Hering, Alexandra Grouiller, Frédéric Sinke, Christopher Marie, Damien show all authors [1 - 13]
Published in		BMC geriatrics. 2020, vol. 20, no. 418, p. 1-19
Abstract		Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that stimulate neuroplasticity and delay or reverse symptoms of cognitive and cerebral decline. To be successful, these regimens should be easily integrated in daily life and intrinsically motivating. This study combines for the first-time protocolled music practice in elderly with cutting-edge neuroimaging and behavioral approaches, comparing two types of musical education. We conduct a two-site Hannover-Geneva randomized intervention study in altogether 155 retired healthy elderly (64-78) years), offering either piano instruction (experimental group) or musical listening awareness (control group). Over 12 months participants receive weekly 1h training and exercise at home for ~30 min. daily. Both groups study different music styles. Subjects are tested at 4 time points (0, 6, and 12 months & post-training (18 months)) on cognitive and perceptual-motor aptitudes and wide-ranging functional and structural neuroimaging and blood sampling. We aim to demonstrate positive transfer effects for faculties traditionally described to decline with age, particularly in the piano group: executive functions, working memory, processing speed, abstract thinking and fine motor skills. Benefits in both groups may show for verbal memory, hearing in noise and subjective well-being. In association with these behavioral benefits we anticipate functional and structural brain plasticity in temporal (medial and lateral), prefrontal and parietal areas, and in the basal ganglia.
Keywords		Music induced brain and behavioral plasticity — Age-related cognitive decline — One-year music practice — Randomized controlled trial — Working memory — Executive functions — Magnetic resonance imaging (MRI) — Voxel based — Morphometry (VBM) — Diffusion tensor imaging (DTI) — Multivariate data-driven analyses
Identifiers		DOI: 10.1186/s12877-020-01761-y PMID: 33087078
Full text		Article (Published version) (746 Kb) - Free access Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576734/
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de psychologie et des sciences de l'éducation / Section de psychologie
Research groups		Geneva Musical Minds Lab, Geneva School of Health Sciences HES-SO Affective sciences Laboratoire du vieillissement cognitif Neuroscience de l'émotion et dynamiques affectives (NEAD) Traitement d'images médicales (893)
Projects		Swiss National Science Foundation: 100019E-170410 Autre: German Research Foundation / Deutsche Forschungsgemeinschaft (DFG no. 323965454)
Citation (ISO format)		JAMES, Clara et al. Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music. In: BMC Geriatrics, 2020, vol. 20, n° 418, p. 1-19. doi: 10.1186/s12877-020-01761-y https://archive-ouverte.unige.ch/unige:148121