Comprehensive chemical profiling for plant chemotaxonomy and quality control of herbal medicines – An MS-based metabolomics and molecular network perspective

Afzan, Adlin

doi:10.13097/archive-ouverte/unige:147476

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Comprehensive chemical profiling for plant chemotaxonomy and quality control of herbal medicines – An MS-based metabolomics and molecular network perspective
Author		Afzan, Adlin
Directors		Wolfender, Jean-Luc Hadiani Ismail, Nor
Defense		Thèse de doctorat : Univ. Genève, 2020 - Sc. 5439 - 2020/01/10
Abstract		Insightful knowledge of plant secondary metabolites remains valuable in plant classifications, particularly for the establishment of the evolutionary relationship between species and authentication of medicinal plants. This PhD project aims to improve chemotaxonomy methods for complementing taxonomy classifications and quality control of herbal medicines. This work relies on high-resolution mass spectrometry metabolomics applied to the herbarium specimens of Gentianaceae family and field collections of Ficus deltoidea varieties. For this, rapid fingerprints of plant extracts and a molecular-network based annotation strategy for deep metabolome profiling were developed. This thesis illustrates the value of chemotaxonomy in the differentiation of closely related plant species and opens the possibility of using a small portion of herbarium collections for drug discovery. Finally, the in-depth chemical knowledge for F. deltoidea obtained in this thesis is now available as a foundation for future research in rationalizing its traditional therapeutic use.
Keywords		Natural products — Metabolomics — Gentianaceae — Ficus deltoidea — Quality control — Chemotaxonomy
Identifiers		DOI: 10.13097/archive-ouverte/unige:147476 URN: urn:nbn:ch:unige-1474760
Full text		Thesis (12.4 MB) - Limited access to UNIGE (until 2025-01-13)
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		AFZAN, Adlin. Comprehensive chemical profiling for plant chemotaxonomy and quality control of herbal medicines – An MS-based metabolomics and molecular network perspective. Université de Genève. Thèse, 2020. doi: 10.13097/archive-ouverte/unige:147476 https://archive-ouverte.unige.ch/unige:147476