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A catalog of genetic loci associated with kidney function from analyses of a million individuals

Wuttke, Matthias
Li, Yong
Li, Man
Sieber, Karsten B.
Feitosa, Mary F.
Gorski, Mathias
Tin, Adrienne
Wang, Lihua
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Published in Nature genetics. 2019, vol. 51, no. 6, p. 957-972
Abstract Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n?=?1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n?=?416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Keywords Chromosome MappingEuropean Continental Ancestry GroupGenetic Association Studies/methodsGenetic Predisposition to DiseaseGenome-Wide Association StudyGlomerular Filtration RateHumansInheritance PatternsKidney Function TestsPhenotypePolymorphism, Single NucleotideQuantitative Trait LociQuantitative Trait, HeritableRenal Insufficiency, Chronic/genetics/physiopathology/urineUromodulin/urine
PMID: 31152163
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Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888/
Research group Traits génétiques complexes (901)
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WUTTKE, Matthias et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. In: Nature Genetics, 2019, vol. 51, n° 6, p. 957-972. doi: 10.1038/s41588-019-0407-x https://archive-ouverte.unige.ch/unige:147447

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Deposited on : 2021-01-15

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