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Scientific article
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English

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Contributors

Coste, A T; Kritikos, A; Li, J; Khanna, N; Goldenberger, D; Garzoni, C; Zehnder, C; Boggian, K; Neofytos, Dionysios; Riat, Arnaud; Bachmann, D; Sanglard, D; Lamoth, F; The Fungal Infection Network of Switzerland (FUNGINOS)

Published in

Infection, vol. 48, no. 5, p. 761-766

Publication date

2020

Abstract

Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.

UNIGE affiliation entities

Funding

  • Autre - Fungal Infection Network of Switzerland (FUNGINOS)

Citation (ISO format)

COSTE, A T et al. Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. In: Infection, 2020, vol. 48, n° 5, p. 761–766. doi: 10.1007/s15010-020-01475-8

Main files (1)

Article (Published version)
CC BY

Identifiers

Additional URL for this publication

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518979/

Journal ISSN

0300-8126
259views
332downloads

Technical informations

Creation

13/10/2020 14:37:00

First validation

13/10/2020 14:37:00

Update

13/10/2025 16:39:33

Status update

15/03/2023 23:51:51

Last indexation

10/11/2026 17:40:08
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