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Scientific article
Review
English

Humoral immunity against HDL particle: a new perspective in cardiovascular diseases?

Contributors

Satta Poschung, Nathalie; Frias, Miguel; Vuilleumier, Nicolas; Pagano, Sabrina

Published in

Current Pharmaceutical Design, vol. 25, no. 29, p. 3128-3146

Publication date

2019

Abstract

Autoimmune diseases are closely associated with cardiovascular diseases (CVD). Over the last decades, the comprehension of atherosclerosis, the principal initiator of CVD, evolved from a lipidcentered disease to a predominant inflammatory and immune response-driven disease displaying features of autoimmunity against a broad range of auto-antigens, including lipoproteins. Among them, high density lipoproteins (HDL) are important actors of cholesterol transport and bear several anti-atherogenic properties, raising a growing interest as therapeutic targets to decrease atherosclerosis and CVD burden, with nevertheless rather disappointing results so far. Reflecting HDL composition complexity, autoimmune responses and autoantibodies against various HDL components have been reported.

Keywords

  • Atherosclerosis/immunology
  • Autoantibodies/immunology
  • Autoimmunity
  • Biomarkers/blood
  • Cardiovascular Diseases/immunology
  • Cholesterol
  • HDL
  • Humans
  • Immunity
  • Humoral
  • Lipoproteins
  • HDL/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

SATTA POSCHUNG, Nathalie et al. Humoral immunity against HDL particle: a new perspective in cardiovascular diseases? In: Current Pharmaceutical Design, 2019, vol. 25, n° 29, p. 3128–3146. doi: 10.2174/1381612825666190830164917

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1381-6128
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Technical informations

Creation

21/08/2020 09:05:00

First validation

21/08/2020 09:05:00

Update

23/01/2025 11:28:30

Status update

23/01/2025 11:28:30

Last indexation

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