In this paper, we argue that structural inequalities by race, class and gender are responsible for asymmetries in the costs of COVID-19 pandemic borne by individuals in the U.S., both in terms of health outcomes and economic well-being. Minority and low-income individuals are more exposed to contamination and more likely to develop severe infections that can lead to hospitalization and death due to COVID-19. Likewise, women and racialized populations are experiencing higher economic impacts in the form of job losses and fall in their well being. Policies designed to combat the epidemic have been failing in closing the racial and class gap. The coronavirus outbreak is exacerbating biases and increasing social, gender, and racial gaps—and consequently increasing the length and severity of the crisis.