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Title

2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer

Authors
Farge, Dominique
Frere, Corinne
Connors, Jean M
Ay, Cihan
Khorana, Alok A
Munoz, Andres
Brenner, Benjamin
Kakkar, Ajay
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Collaboration
Published in The Lancet Oncology. 2019, vol. 20, no. 10, p. e566-e581
Abstract Venous thromboembolism (VTE) is the second leading cause of death in patients with cancer. These patients are at a high risk of VTE recurrence and bleeding during anticoagulant therapy. The International Initiative on Thrombosis and Cancer is an independent academic working group aimed at establishing a global consensus for the treatment and prophylaxis of VTE in patients with cancer. The International Initiative on Thrombosis and Cancer last updated its evidence-based clinical practice guidelines in 2016 with a free, web-based mobile phone application, which was subsequently endorsed by the International Society on Thrombosis and Haemostasis. The 2019 International Initiative on Thrombosis and Cancer clinical practice guidelines, which are based on a systematic review of the literature published up to December, 2018, are presented along with a Grading of Recommendations Assessment Development and Evaluation scale methods, with the support of the French National Cancer Institute. These guidelines were reviewed by an expanded international advisory committee and endorsed by the International Society on Thrombosis and Haemostasis. Results from head-to-head clinical trials that compared direct oral anticoagulant with low-molecular-weight heparin are also summarised, along with new evidence for the treatment and prophylaxis of VTE in patients with cancer.
Keywords Anticoagulants/administration & dosage/therapeutic useCentral Venous Catheters/adverse effectsFactor Xa Inhibitors/therapeutic useFondaparinux/therapeutic useHeparin, Low-Molecular-Weight/administration & dosage/therapeutic useHumansNeoplasms/complications/surgeryVena Cava FiltersVenous Thromboembolism/drug therapy/etiology/prevention & controlVitamin K/antagonists & inhibitors
Identifiers
PMID: 31492632
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Article (Published version) (151 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Appendix (1.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://www.sciencedirect.com/science/article/pii/S1470204519303365
Structures
Research group La maladie thromboembolique veineuse (808)
Citation
(ISO format)
FARGE, Dominique et al. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. In: The Lancet Oncology, 2019, vol. 20, n° 10, p. e566-e581. doi: 10.1016/S1470-2045(19)30336-5 https://archive-ouverte.unige.ch/unige:147133

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Deposited on : 2021-01-12

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