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Enantioselective hydrogenation on cinchona-modified metal catalysts: Mechanistic implication of acid additive

Huck, W. R.
Mallat, T.
Baiker, Alfons
Published in Journal of Catalysis. 2002, vol. 205, no. 1, p. 213-216
Abstract The enantioselective hydrogenation of 4-hydroxy-6-methyl-2-pyrone in the presence of acetic acid and trifluoroacetic acid has been studied on cinchonidine-modified Pd/TiO2. Catalytic experiments and theoretical calculations indicate the formation of a cinchonidine–trifluoroacetic acid cyclic ion pair. We propose that this is the actual modifier, which interacts with 4-hydroxy-6-methyl-2-pyrone in the enantiodifferentiating step. The new mechanistic model is assumed to be valid also for other reactions over cinchona-modified Pt or Pd, in the presence of trifluoroacetic acid.
Stable URL https://archive-ouverte.unige.ch/unige:14710
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Deposited on : 2011-03-18

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