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Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects

Published in Neurodegenerative Diseases. 2019, vol. 19, no. 3-4, p. 139-147
Abstract Hippocampal volume loss (HVL), PET-documented brain amyloid accumulation, and APOE-ε4 status are predictive biomarkers of the transition from mild cognitive impairment to Alzheimer disease (AD). In asymptomatic cases, the role of these biomarkers remains ambiguous. In contrast to the idea that HVL occurs in late phases of neurodegeneration, recent contributions indicate that it might occur before abnormal amyloid PET occurrence in elderly subjects and that its severity could be only marginally related to APOE variants. Using a longitudinal design, we examined the determinants of HVL in our sample, i.e., brain amyloid burden and the presence of APOE-ε4, and made a longitudinal assessment of cognitive functions.
Keywords AgedAged, 80 and overAmyloid beta-Peptides/metabolismApolipoprotein E4/geneticsBrain/diagnostic imaging/metabolismCognitive Aging/physiology/psychologyFemaleHippocampus/diagnostic imaging/pathologyHumansLongitudinal StudiesMagnetic Resonance ImagingMalePositron-Emission Tomography
PMID: 31846965
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Research groups Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
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HALLER, Sven et al. Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. In: Neurodegenerative Diseases, 2019, vol. 19, n° 3-4, p. 139-147. doi: 10.1159/000504302 https://archive-ouverte.unige.ch/unige:147046

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Deposited on : 2021-01-08

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