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Scientific article
Open access
English

Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems

Published inPharmaceutics, vol. 13, no. 1, no. Special Issue Microencapsulation for the Therapeutic Delivery of Drugs, 60
Publication date2021
Abstract

Osteoarthritis (OA) is a complex multi-target disease with an unmet medical need for the development of therapies that slow and potentially revert disease progression. Intra-articular (IA) delivery has seen a surge in osteoarthritis research in recent years. As local administration of molecules, this represents a way to circumvent systemic drug delivery struggles. When developing intra-articular formulations, the main goals are a sustained and controlled release of therapeutic drug doses, taking into account carrier choice, drug molecule, and articular joint tissue target. Therefore, the selection of models is critical when developing local administration formulation in terms of accurate outcome assessment, target and off-target effects and relevant translation to in vivo. The current review highlights the applications of OA in vitro models in the development of IA formulation by means of exploring their advantages and disadvantages. In vitro models are essential in studies of OA molecular pathways, understanding drug and target interactions, assessing cytotoxicity of carriers and drug molecules, and predicting in vivo behaviors. However, further understanding of molecular and tissue-specific intricacies of cellular models for 2D and 3D needs improvement to accurately portray in vivo conditions.

Keywords
  • Osteoarthritis
  • Intra-articular drug delivery systems
  • Synovium
  • Cartilage
  • In vitro cellular models
  • Synoviocytes
  • Chondrocytes
Citation (ISO format)
DE LACERDA SALGADO, Carlota, JORDAN, Olivier, ALLÉMANN, Eric. Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems. In: Pharmaceutics, 2021, vol. 13, n° 1, p. 60. doi: 10.3390/pharmaceutics13010060
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ISSN of the journal1999-4923
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Technical informations

Creation01/07/2021 6:53:00 PM
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Update time03/15/2023 11:48:42 PM
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