UNIGE document Scientific Article
previous document  unige:146825  next document
add to browser collection
Title

Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola

Authors
Bonnet, Julien
Vignoles, Philippe
Gedeão, Vatunga
Josenando, Theophile
Ndung'u, Joseph M
show hidden authors show all authors [1 - 11]
Published in BioMed research international. 2019, vol. 2019, no. 6070176, p. 1-9
Abstract Human African Trypanosomiasis may become manageable in the next decade with fexinidazole. However, currently stage diagnosis remains difficult to implement in the field and requires a lumbar puncture. Our study of an Angolan cohort of T. b. gambiense-infected patients used other staging criteria than those recommended by the WHO. We compared WHO criteria (cell count and parasite identification in the CSF) with two biomarkers (neopterin and CXCL-13) which have proven potential to diagnose disease stage or relapse. Biological, clinical, and neurological data were analysed from a cohort of 83 patients. A neopterin concentration below 15.5 nmol/L in the CSF denoted patients with stage 1 disease, and a concentration above 60.31 nmol/L characterized patients with advanced stage 2 (trypanosomes in CSF and/or cytorachia higher than 20 cells) disease. CXCL-13 levels below 91.208 pg/mL denoted patients with stage 1 disease, and levels of CXCL-13 above 395.45 pg/mL denoted patients with advanced stage 2 disease. Values between these cut-offs may represent patients with intermediate stage disease. Our work supports the existence of an intermediate stage in HAT, and CXCL-13 and neopterin levels may help to characterize it.
Identifiers
PMID: 31886231
Full text
Structures
Research group Groupe de Protéomique biomédicale (635)
Citation
(ISO format)
BONNET, Julien et al. Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola. In: BioMed Research International, 2019, vol. 2019, n° 6070176, p. 1-9. doi: 10.1155/2019/6070176 https://archive-ouverte.unige.ch/unige:146825

90 hits

38 downloads

Update

Deposited on : 2020-12-18

Export document
Format :
Citation style :