Duration of preclinical, prodromal, and dementia stages of Alzheimer&#039;s disease in relation to age, sex, and APOE genotype

Vermunt, Lisa; Sikkes, Sietske A M; van den Hout, Ardo; Handels, Ron; Bos, Isabelle; van der Flier, Wiesje M; Kern, Silke; Ousset, Pierre-Jean; Maruff, Paul; Skoog, Ingmar; Verhey, Frans R J; Freund-Levi, Yvonne; Tsolaki, Magda; Wallin, Åsa K; Olde Rikkert, Marcel; Soininen, Hilkka; Spiru, Luisa; Zetterberg, Henrik; Blennow, Kaj; Scheltens, Philip; Muniz-Terrera, Graciela; Visser, Pieter Jelle

doi:10.1016/j.jalz.2019.04.001

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Title		Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
Authors		Vermunt, Lisa Sikkes, Sietske A M van den Hout, Ardo Handels, Ron Bos, Isabelle van der Flier, Wiesje M Kern, Silke Ousset, Pierre-Jean Maruff, Paul Skoog, Ingmar Verhey, Frans R J Freund-Levi, Yvonne Tsolaki, Magda Wallin, Åsa K Olde Rikkert, Marcel Soininen, Hilkka Spiru, Luisa Zetterberg, Henrik Blennow, Kaj Scheltens, Philip Muniz-Terrera, Graciela Visser, Pieter Jelle show all authors [1 - 22]
Collaboration		Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups With : Zekry Berger, Dina Selma
Published in		Alzheimer's & Dementia. 2019, vol. 15, no. 7, p. 888-898
Abstract		We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.
Keywords		Aged — Alleles — Alzheimer Disease/genetics/pathology — Amyloid — Apolipoprotein E4/genetics — Biomarkers/cerebrospinal fluid — Cognitive Dysfunction/pathology — Disease Progression — Female — Genotype — Humans — Longitudinal Studies — Male — Positron-Emission Tomography — Prodromal Symptoms — Sex Factors — Time Factors — tau Proteins/cerebrospinal fluid
Identifiers		DOI: 10.1016/j.jalz.2019.04.001 PMID: 31164314
Full text		Article (Accepted version) (751 Kb) - Free access Other version: https://www.sciencedirect.com/science/article/abs/pii/S1552526019300846
Structures		Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Citation (ISO format)		VERMUNT, Lisa et al. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. In: Alzheimer's & Dementia, 2019, vol. 15, n° 7, p. 888-898. doi: 10.1016/j.jalz.2019.04.001 https://archive-ouverte.unige.ch/unige:146823