Intra-monocyte Pharmacokinetics of Imiglucerase Supports a Possible Personalized Management of Gaucher Disease Type 1

Berger, Juliette; Vigan, Marie; Pereira, Bruno; Nguyen, Thu Thuy; Froissart, Roseline; Belmatoug, Nadia; Dalbiès, Florence; Masseau, Agathe; Rose, Christian; De Roux Serratrice, Christine; Pers, Yves-Marie; Bertchansky, Ivan; Camou, Fabrice; Bengherbia, Monia; Bourgne, Céline; Caillaud, Catherine; Pettazzoni, Magali; Berrahal, Amina; Stirnemann, Jérôme; Mentré, France; Berger, Marc G

doi:10.1007/s40262-018-0708-8

Scientific article

English

Intra-monocyte Pharmacokinetics of Imiglucerase Supports a Possible Personalized Management of Gaucher Disease Type 1

Published inClinical Pharmacokinetics, vol. 58, no. 4, p. 469-482

Publication date2019

Abstract

Intravenous imiglucerase enzyme replacement therapy for Gaucher disease type 1 administered every 2 weeks is at variance with the imiglucerase plasma half-life of a few minutes. We hypothesized that studying the pharmacokinetics of imiglucerase in blood Gaucher disease type 1 monocytes would be more relevant for understanding enzyme replacement therapy responses.

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Child
Enzyme Replacement Therapy
Female
Gaucher Disease/drug therapy/metabolism
Glucosylceramidase/metabolism/pharmacokinetics/therapeutic use
Humans
Male
Middle Aged
Models, Biological
Monocytes/metabolism
Precision Medicine
Young Adult

Affiliation entities

Research groups

Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)

Citation (ISO format)

BERGER, Juliette et al. Intra-monocyte Pharmacokinetics of Imiglucerase Supports a Possible Personalized Management of Gaucher Disease Type 1. In: Clinical Pharmacokinetics, 2019, vol. 58, n° 4, p. 469–482. doi: 10.1007/s40262-018-0708-8

Article (Published version)

Appendix

Identifiers

PID : unige:146598
DOI : 10.1007/s40262-018-0708-8
PMID : 30128966

Additional URL for this publicationhttps://link.springer.com/article/10.1007%2Fs40262-018-0708-8

Journal ISSN0312-5963

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First validation15/10/2020 16:17:00

Update15/03/2023 23:44:24

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Intra-monocyte Pharmacokinetics of Imiglucerase Supports a Possible Personalized Management of Gaucher Disease Type 1

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