Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review

Iudici, Michele; Porcher, Raphaël; Riveros, Carolina; Ravaud, Philippe

doi:10.1136/annrheumdis-2018-214544

Scientific article

Review

English

Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review

ContributorsIudici, Michele

; Porcher, Raphaël; Riveros, Carolina; Ravaud, Philippe

Published inAnnals of the Rheumatic Diseases, vol. 78, no. 4, p. 562-569

Publication date2019

Abstract

Objective: To assess to what extent time-dependent biases (ie, immortal time bias (ITB) and time-lag bias (TLB)) occur in the latest rheumatology observational studies, describe their main mechanisms and increase the awareness on this topic.

Keywords

Autoimmune diseases
Epidemiology
Treatment

Affiliation entities

Not a UNIGE publication

Research groups

Recherche clinique dans les rhumatismes inflammatoires (1010)

Citation (ISO format)

IUDICI, Michele et al. Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review. In: Annals of the Rheumatic Diseases, 2019, vol. 78, n° 4, p. 562–569. doi: 10.1136/annrheumdis-2018-214544

Article (Published version)

Identifiers

PID : unige:146595
DOI : 10.1136/annrheumdis-2018-214544
PMID : 30755417

Journal ISSN0003-4967

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613downloads

Creation15/10/2020 11:18:00

First validation15/10/2020 11:18:00

Update08/09/2025 07:37:25

Status update08/09/2025 07:37:25

Last indexation08/09/2025 07:38:17

Archive ouverte UNIGE

Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review

Objective: To assess to what extent time-dependent biases (ie, immortal time bias (ITB) and time-lag bias (TLB)) occur in the latest rheumatology observational studies, describe their main mechanisms and increase the awareness on this topic.

Technical informations