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Scientific article
Open access
English

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses

Published inVirology Journal, vol. 15, no. 1, 68
Publication date2018
Abstract

With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to conventional avian and human influenza A viruses. To this end, three bat species (Eidolon helvum, Carollia perspicillata and Tadarida brasiliensis) of lungepithelial cells were separately infected with two avian and two human influenza viruses to determine their relativehost innate immune resistance to infection.

Keywords
  • Influenza
  • Bats
  • Epithelial cells
  • Host resistance
  • Innate immunity
  • Inflammation
  • Animals
  • Cell Survival
  • Cells, Cultured
  • Chiroptera
  • Dogs
  • Epithelial Cells/virology
  • Gene Expression
  • Host Specificity
  • Influenza A virus/classification/immunology
  • Lung/cytology/immunology
  • Madin Darby Canine Kidney Cells
  • Neuraminidase/pharmacology
  • Orthomyxoviridae Infections/virology
  • Receptors, Virus/metabolism
  • Viral Proteins/genetics
  • Virus Release/drug effects
  • Virus Replication
Citation (ISO format)
SLATER, Tessa, ECKERLE, Isabella Anne, CHANG, Kin-Chow. Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses. In: Virology Journal, 2018, vol. 15, n° 1, p. 68. doi: 10.1186/s12985-018-0979-6
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Article (Published version)
Identifiers
ISSN of the journal1743-422X
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67downloads

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