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Scientific article
English

Preserved Extrastriatal 123I-FP-CIT Binding in Scans Without Evidence of Dopaminergic Deficit (SWEDD)

Published inMolecular Imaging and Biology, vol. 22, no. 6, p. 1592-1599
Publication date2020
Abstract

Scans without evidence of dopaminergic deficit (SWEDD) have been initially described in a minority of subjects with suspected Parkinson's disease (PD). Although a highly controversial entity, longitudinal studies showed that SWEDD cases mostly involve non-degenerative conditions mimicking PD or misattribution of scan images to normal status. Using the Parkinson's Progression Markers Initiative (PPMI) cohort, we undertook a case-controlled analysis of [123I]N-ω-fluoropropyl-2β-carbomethoxy-iodophenyl nortropane ([123I]FP-CIT) single photon emission computed tomography (SPECT) images to measure extrastriatal serotonergic transporter (SERT) density in SWEDD and PD.

Keywords
  • Degenerative parkinsonism
  • Dopamine
  • Extrastriatal
  • SPECT
  • Serotonin
  • [123I]FP-CIT
Citation (ISO format)
NICASTRO, Nicolas, BURKHARD, Pierre, GARIBOTTO, Valentina. Preserved Extrastriatal 123I-FP-CIT Binding in Scans Without Evidence of Dopaminergic Deficit (SWEDD). In: Molecular Imaging and Biology, 2020, vol. 22, n° 6, p. 1592–1599. doi: 10.1007/s11307-020-01502-y
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ISSN of the journal1536-1632
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Creation11/16/2020 9:02:00 AM
First validation11/16/2020 9:02:00 AM
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