Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

Leclercq, Christophe; Burri, Haran Kumar; Curnis, Antonio; Delnoy, Peter Paul; Rinaldi, Christopher A; Sperzel, Johannes; Lee, Kwangdeok; Cohorn, Clay; Thibault, Bernard; MORE-CRT MPP Investigators

doi:10.1016/j.ahj.2018.12.004

Article scientifique

Anglais

Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

Contributeurs/tricesLeclercq, Christophe; Burri, Haran Kumar; Curnis, Antonio; Delnoy, Peter Paul; Rinaldi, Christopher A; Sperzel, Johannes; Lee, Kwangdeok; Cohorn, Clay; Thibault, Bernard; MORE-CRT MPP Investigators

Publié dansAmerican Heart Journal, vol. 209, p. 1-8

Date de publication2019

Résumé

Although cardiac resynchronization therapy (CRT) is beneficial in most heart failure patients, up to 40% do not respond to CRT. Data from the MultiPoint Pacing (MPP) IDE trial and MORE-CRT MPP-PHASE I study suggest improved response in subjects in the MPP arm-programmed with wide left ventricular (LV) electrode anatomical separation (≥30 mm) and shortest timing delays of 5 milliseconds (MPP-AS)-compared with quadripolar biventricular (BiV) pacing.

Mots-clés

Aged
Cardiac Resynchronization Therapy/methods
Female
Follow-Up Studies
Heart Failure/physiopathology/therapy
Humans
Male
Prospective Studies
Stroke Volume/physiology
Time Factors
Treatment Outcome
Ventricular Function
Left/physiology
Ventricular Remodeling

Structure d'affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Groupe de recherche

L'athérosclérose et ses complications cliniques (591)

Citation (format ISO)

LECLERCQ, Christophe et al. Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II). In: American Heart Journal, 2019, vol. 209, p. 1–8. doi: 10.1016/j.ahj.2018.12.004

Article (Published version)

Identifiants

PID : unige:145532
DOI : 10.1016/j.ahj.2018.12.004
PMID : 30616009

ISSN du journal0002-8703

150vues

0téléchargements

Création12/10/2020 14:53:00

Première validation12/10/2020 14:53:00

Heure de mise à jour15/03/2023 23:37:04

Changement de statut15/03/2023 23:37:03

Dernière indexation17/01/2024 11:47:50

Archive ouverte UNIGE

Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

Informations techniques