Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

Leclercq, Christophe; Burri, Haran Kumar; Curnis, Antonio; Delnoy, Peter Paul; Rinaldi, Christopher A; Sperzel, Johannes; Lee, Kwangdeok; Cohorn, Clay; Thibault, Bernard; MORE-CRT MPP Investigators

doi:10.1016/j.ahj.2018.12.004

Scientific article

English

Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

ContributorsLeclercq, Christophe; Burri, Haran Kumar; Curnis, Antonio; Delnoy, Peter Paul; Rinaldi, Christopher A; Sperzel, Johannes; Lee, Kwangdeok; Cohorn, Clay; Thibault, Bernard; MORE-CRT MPP Investigators

Published inAmerican Heart Journal, vol. 209, p. 1-8

Publication date2019

Abstract

Although cardiac resynchronization therapy (CRT) is beneficial in most heart failure patients, up to 40% do not respond to CRT. Data from the MultiPoint Pacing (MPP) IDE trial and MORE-CRT MPP-PHASE I study suggest improved response in subjects in the MPP arm-programmed with wide left ventricular (LV) electrode anatomical separation (≥30 mm) and shortest timing delays of 5 milliseconds (MPP-AS)-compared with quadripolar biventricular (BiV) pacing.

Keywords

Aged
Cardiac Resynchronization Therapy/methods
Female
Follow-Up Studies
Heart Failure/physiopathology/therapy
Humans
Male
Prospective Studies
Stroke Volume/physiology
Time Factors
Treatment Outcome
Ventricular Function
Left/physiology
Ventricular Remodeling

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

L'athérosclérose et ses complications cliniques (591)

Citation (ISO format)

LECLERCQ, Christophe et al. Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II). In: American Heart Journal, 2019, vol. 209, p. 1–8. doi: 10.1016/j.ahj.2018.12.004

Article (Published version)

Identifiers

PID : unige:145532
DOI : 10.1016/j.ahj.2018.12.004
PMID : 30616009

Journal ISSN0002-8703

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Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

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