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Scientific article
Open access
English

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Published inJournal of Hepatology, vol. 71, no. 3, p. 505-515
Publication date2019
Abstract

The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal changes in a large number of brain metabolites together with biochemical, histological and behavioural assessment. We hypothesized that neurometabolic changes are detectable very early, and that these early changes will offer insight into the primary events underpinning HE.

Keywords
  • Bile duct ligated
  • Brain metabolism
  • Cholestasis
  • Chronic liver disease
  • Hepatic encephalopathy
  • In vivo proton magnetic resonance spectroscopy
  • Rats
Citation (ISO format)
BRAISSANT, Olivier et al. Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. In: Journal of Hepatology, 2019, vol. 71, n° 3, p. 505–515. doi: 10.1016/j.jhep.2019.05.022
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Article (Published version)
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ISSN of the journal0168-8278
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Technical informations

Creation10/15/2020 4:38:00 PM
First validation10/15/2020 4:38:00 PM
Update time03/15/2023 11:35:35 PM
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