Privat-docent thesis
Open access

Synaptic remodeling at the heart of memory processes

ContributorsDe Roo, Mathias
Defense date2020

At the turn of the 21st century, the development of laser scanning microscopy combined with the methods of neuronal transfection with fluorescent proteins permitted the first ever real-time visualization of excitatory synapses following the induction of learning- related patterns of activity in living neurons in vitro, and later following sensory experience in living animals. These techniques, that are still improving today, led to the discovery of a causal link between learning and memory and structural plasticity of synapses, leading to long-term neuronal network remodeling. It has opened a new era in the study of the mechanisms that underlie learning and memory, and provided new therapeutic leads for brain disorders. This thesis describes my scientific contribution in this context.

  • Learning and Memory
  • Hippocampus
  • Dendritic spines
  • Plasticity
  • Synaptogenesis
  • Confocal imaging
Citation (ISO format)
DE ROO, Mathias. Synaptic remodeling at the heart of memory processes. 2020. doi: 10.13097/archive-ouverte/unige:145460
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Creation11/24/2020 5:29:00 PM
First validation11/24/2020 5:29:00 PM
Update time03/15/2023 11:35:26 PM
Status update03/15/2023 11:35:26 PM
Last indexation01/29/2024 10:26:17 PM
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