UNIGE document Scientific Article - Review
previous document  unige:145429  next document
add to browser collection
Title

The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review

Authors
Zanchi, Davide
Depoorter, Antoinette
Egloff, Laura
Mählmann, Laura
Lang, Undine E
Drewe, Jürgen
Beglinger, Christoph
show hidden authors show all authors [1 - 10]
Published in Neuroscience and biobehavioral reviews. 2017, vol. 80, p. 457-475
Abstract The brain-gut-axis is an interdependent system affecting neural functions and controlling our eating behaviour. In recent decades, neuroimaging techniques have facilitated its investigation. We systematically looked into functional and neurochemical brain imaging studies investigating how key molecules such as ghrelin, glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY), cholecystokinin (CCK), leptin, glucose and insulin influence the function of brain regions regulating appetite and satiety. Of the 349 studies published before July 2016 identified in the database search, 40 were included (27 on healthy and 13 on obese subjects). Our systematic review suggests that the plasma level of ghrelin, the gut hormone promoting appetite, is positively correlated with activation in the pre-frontal cortex (PFC), amygdala and insula and negatively correlated with activation in subcortical areas such as the hypothalamus. In contrast, the plasma levels of glucose, insulin, leptin, PYY, GLP-1 affect the same brain regions conversely. Our study integrates previous investigations of the gut-brain matrix during food-intake and homeostatic regulation and may be of use for future meta-analyses of brain-gut interactions.
Keywords Appetite/physiologyBrain/metabolismGastrointestinal Tract/metabolismHormones/metabolismHumansSatiation/physiology
Identifiers
PMID: 28669754
Full text
Article (Published version) (567 Kb) - public document Free access
Structures
Research group Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Citation
(ISO format)
ZANCHI, Davide et al. The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review. In: Neuroscience and Biobehavioral Reviews, 2017, vol. 80, p. 457-475. doi: 10.1016/j.neubiorev.2017.06.013 https://archive-ouverte.unige.ch/unige:145429

97 hits

52 downloads

Update

Deposited on : 2020-11-27

Export document
Format :
Citation style :