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Title

PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Authors
Rathi, Komal S
Maris, John M
Published in Journal of Experimental & Clinical Cancer Research. 2019, vol. 38, no. 1, 69
Abstract Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in inducing neuroblastoma cell death.
Keywords Cell Death/drug effectsCell Line, TumorGlutathione/metabolismHumansN-Myc Proto-Oncogene Protein/genetics/metabolismNeuroblastoma/drug therapy/genetics/metabolism/pathologyQuinuclidines/pharmacologyThioredoxins/genetics/metabolismTumor Suppressor Protein p53/genetics/metabolism
Identifiers
PMID: 30755224
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Article (Published version) (1.9 MB) - public document Free access
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Supplemental data (6.5 MB) - public document Free access
Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373164/
Structures
Research group Oncologie et hématologie pédiatrique (907)
Citation
(ISO format)
MLAKAR, Vid et al. PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level. In: Journal of Experimental & Clinical Cancer Research, 2019, vol. 38, n° 1, p. 69. doi: 10.1186/s13046-019-1066-6 https://archive-ouverte.unige.ch/unige:145358

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Deposited on : 2020-11-25

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