PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Mlakar, Vid; Mlakar, Simona; Lesne, Laurence; Marino, Denis; Rathi, Komal S; Maris, John M; Ansari Djaberi, Marc Georges; Gumy Pause, Fabienne

doi:10.1186/s13046-019-1066-6

Scientific article

English

PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

ContributorsMlakar, Vid; Mlakar, Simona; Lesne, Laurence; Marino, Denis; Rathi, Komal S; Maris, John M; Ansari Djaberi, Marc Georges; Gumy Pause, Fabienne

Published inJournal of Experimental & Clinical Cancer Research, vol. 38, no. 1, 69

Publication date2019

Abstract

Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in inducing neuroblastoma cell death.

Keywords

Cell Death/drug effects
Cell Line, Tumor
Glutathione/metabolism
Humans
N-Myc Proto-Oncogene Protein/genetics/metabolism
Neuroblastoma/drug therapy/genetics/metabolism/pathology
Quinuclidines/pharmacology
Thioredoxins/genetics/metabolism
Tumor Suppressor Protein p53/genetics/metabolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

MLAKAR, Vid et al. PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level. In: Journal of Experimental & Clinical Cancer Research, 2019, vol. 38, n° 1, p. 69. doi: 10.1186/s13046-019-1066-6

Article (Published version)

CC BY

Identifiers

PID : unige:145358
DOI : 10.1186/s13046-019-1066-6
PMID : 30755224

Commercial URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373164/

Journal ISSN0392-9078

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Creation10/21/2020 1:45:00 PM

First validation10/21/2020 1:45:00 PM

Update time03/15/2023 11:34:16 PM

Status update03/15/2023 11:34:15 PM

Last indexation10/31/2024 8:34:31 PM

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PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in inducing neuroblastoma cell death.

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