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Supplemental data (6.5 MB) - Free accessOther version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373164/
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Titles listPRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level
Titles listPRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level
Scientific Article
unige:145358 
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PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level |
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| Authors | ||
| Published in | Journal of Experimental & Clinical Cancer Research. 2019, vol. 38, no. 1, 69 | |
| Abstract | Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in inducing neuroblastoma cell death. | |
| Keywords | Cell Death/drug effects — Cell Line, Tumor — Glutathione/metabolism — Humans — N-Myc Proto-Oncogene Protein/genetics/metabolism — Neuroblastoma/drug therapy/genetics/metabolism/pathology — Quinuclidines/pharmacology — Thioredoxins/genetics/metabolism — Tumor Suppressor Protein p53/genetics/metabolism | |
| Identifiers | PMID: 30755224 | |
| Full text |
Article (Published version) (1.9 MB) - Free access Supplemental data (440 Kb) - Free access Supplemental data (6.5 MB) - Free access Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373164/ |
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| Structures | ||
| Research group | Oncologie et hématologie pédiatrique (907) | |
| Citation (ISO format) | MLAKAR, Vid et al. PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level. In: Journal of Experimental & Clinical Cancer Research, 2019, vol. 38, n° 1, p. 69. doi: 10.1186/s13046-019-1066-6 https://archive-ouverte.unige.ch/unige:145358 |
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