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Scientific article
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PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Publication date2019
Abstract

Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in inducing neuroblastoma cell death.

Keywords
  • Cell Death/drug effects
  • Cell Line, Tumor
  • Glutathione/metabolism
  • Humans
  • N-Myc Proto-Oncogene Protein/genetics/metabolism
  • Neuroblastoma/drug therapy/genetics/metabolism/pathology
  • Quinuclidines/pharmacology
  • Thioredoxins/genetics/metabolism
  • Tumor Suppressor Protein p53/genetics/metabolism
Citation (ISO format)
MLAKAR, Vid et al. PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level. In: Journal of Experimental & Clinical Cancer Research, 2019, vol. 38, n° 1, p. 69. doi: 10.1186/s13046-019-1066-6
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Article (Published version)
Secondary files (2)
Identifiers
ISSN of the journal0392-9078
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Technical informations

Creation10/21/2020 1:45:00 PM
First validation10/21/2020 1:45:00 PM
Update time03/15/2023 11:34:16 PM
Status update03/15/2023 11:34:15 PM
Last indexation02/12/2024 11:59:08 AM
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