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Title

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Authors
Tcymbarevich, Irina V
Eloranta, Jyrki J
Rossel, Jean-Benoît
Obialo, Nicole
Spalinger, Marianne
Cosin-Roger, Jesus
Lang, Silvia
Kullak-Ublick, Gerd A
show hidden authors show all authors [1 - 15]
CollaborationWith : Petit, Laëtitia Marie
Published in BMC Gastroenterology. 2019, vol. 19, no. 1, 2
Abstract Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161.
Keywords Acidic pHCDIBDInflammatory bowel diseasesRhoAUCCAMPPH-sensing
Identifiers
PMID: 30616622
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Structures
Research group Développement du tube digestif chez les vertébrés (900)
Projects
FNS: 153380 ; 33CS30_148422
FNS: 32473B_156525
Citation
(ISO format)
TCYMBAREVICH, Irina V et al. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation. In: BMC Gastroenterology, 2019, vol. 19, n° 1, p. 2. doi: 10.1186/s12876-018-0922-8 https://archive-ouverte.unige.ch/unige:145299

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Deposited on : 2020-11-25

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