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Scientific article
Open access
English

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Published inBMC Gastroenterology, vol. 19, no. 1, 2
Publication date2019
Abstract

Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161.

Keywords
  • Acidic pH
  • CD
  • IBD
  • Inflammatory bowel diseases
  • RhoA
  • UC
  • CAMP
  • PH-sensing
Citation (ISO format)
TCYMBAREVICH, Irina V et al. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation. In: BMC Gastroenterology, 2019, vol. 19, n° 1, p. 2. doi: 10.1186/s12876-018-0922-8
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Article (Published version)
Identifiers
ISSN of the journal1471-230X
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Technical informations

Creation10/15/2020 5:17:00 PM
First validation10/15/2020 5:17:00 PM
Update time03/15/2023 11:33:41 PM
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