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Scientific article
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English

Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial

Published inOpen Heart, vol. 6, no. 2, e001149
Publication date2019
Abstract

The 16-week, randomised, double-blind Sildenafil in Treatment-Naïve Children, Aged1-17 years, with Pulmonary Arterial Hypertension (STARTS-1) study assessed the effect of sildenafil on cardiopulmonary exercise testing (CPET) in treatment-naïve paediatric patients with pulmonary arterial hypertension (PAH) and included a long-term extension (STARTS-2). CPET has rarely been performed in paediatric patients and we assessed both aerobic capacity with peak oxygen consumption (PVO2) and ventilatory inefficiency with the slope of ventilation to carbon dioxide production (VE/VCO2 slope).

Keywords
  • exercise ECG
  • paediatric cardiac function
  • pulmonary arterial hypertension (PAH)
Citation (ISO format)
RUSSELL, Stuart et al. Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial. In: Open Heart, 2019, vol. 6, n° 2, p. e001149. doi: 10.1136/openhrt-2019-001149
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Article (Published version)
Identifiers
ISSN of the journal2053-3624
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Technical informations

Creation10/16/2020 2:48:00 PM
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