en
Scientific article
Open access
English

Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS

Published inPLOS ONE, vol. 14, no. 11, e0225468
Publication date2019
Abstract

Endogenous tissue mediators inducing lung inflammation in the context of ventilator-induced lung injury (VILI) and acute respiratory distress syndrome (ARDS) are ill-defined.

Keywords
  • A549 Cells
  • Alarmins/metabolism
  • Animals
  • Bronchoalveolar Lavage Fluid/chemistry
  • Culture Media
  • Conditioned/pharmacology
  • DNA
  • Mitochondrial/metabolism
  • Humans
  • Interleukin-8/genetics/metabolism
  • Macrophages/cytology/drug effects/metabolism
  • Male
  • Mitochondria/drug effects/genetics/metabolism
  • Neutrophil Infiltration/drug effects
  • Oligoribonucleotides
  • Antisense/metabolism
  • Rabbits
  • Respiratory Distress Syndrome
  • Adult/metabolism/pathology
  • Stress
  • Physiological
  • Toll-Like Receptor 9/antagonists & inhibitors/genetics/metabolism
  • Ventilator-Induced Lung Injury/metabolism/pathology
Funding
  • Swiss National Science Foundation - #310030-141143
Citation (ISO format)
GRAZIOLI, Serge et al. Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS. In: PLOS ONE, 2019, vol. 14, n° 11, p. e0225468. doi: 10.1371/journal.pone.0225468
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
162views
59downloads

Technical informations

Creation10/15/2020 5:37:00 PM
First validation10/15/2020 5:37:00 PM
Update time03/15/2023 11:33:22 PM
Status update03/15/2023 11:33:21 PM
Last indexation02/12/2024 11:59:00 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack